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Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools

[Image: see text] We report the fabrication of aqueous multimodal imaging nanocomposites based on superparamagnetic nanoparticles (MNPs) and two different sizes of photoluminescent upconverting nanoparticles (UCNPs). The controlled and simultaneous incorporation of both types of nanoparticles (NPs)...

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Autores principales: Materia, Maria Elena, Pernia Leal, Manuel, Scotto, Marco, Balakrishnan, Preethi Bala, Kumar Avugadda, Sahitya, García-Martín, María L., Cohen, Bruce E., Chan, Emory M., Pellegrino, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091499/
https://www.ncbi.nlm.nih.gov/pubmed/28945361
http://dx.doi.org/10.1021/acs.bioconjchem.7b00432
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author Materia, Maria Elena
Pernia Leal, Manuel
Scotto, Marco
Balakrishnan, Preethi Bala
Kumar Avugadda, Sahitya
García-Martín, María L.
Cohen, Bruce E.
Chan, Emory M.
Pellegrino, Teresa
author_facet Materia, Maria Elena
Pernia Leal, Manuel
Scotto, Marco
Balakrishnan, Preethi Bala
Kumar Avugadda, Sahitya
García-Martín, María L.
Cohen, Bruce E.
Chan, Emory M.
Pellegrino, Teresa
author_sort Materia, Maria Elena
collection PubMed
description [Image: see text] We report the fabrication of aqueous multimodal imaging nanocomposites based on superparamagnetic nanoparticles (MNPs) and two different sizes of photoluminescent upconverting nanoparticles (UCNPs). The controlled and simultaneous incorporation of both types of nanoparticles (NPs) was obtained by controlling the solvent composition and the addition rate of the destabilizing solvent. The magnetic properties of the MNPs remained unaltered after their encapsulation into the polymeric beads as shown by the T2 relaxivity measurements. The UCNPs maintain photoluminescent properties even when embedded with the MNPs into the polymer bead. Moreover, the light emitted by the magnetic and upconverting nanobeads (MUCNBs) under NIR excitation (λ(exc) = 980 nm) was clearly observed through different thicknesses of agarose gel or through a mouse skin layer. The comparison with magnetic and luminescent nanobeads based on red-emitting quantum dots (QDs) demonstrated that while the QD-based beads show significant autofluorescence background from the skin, the signal obtained by the MUCNBs allows a decrease in this background. In summary, these results indicate that MUCNBs are good magnetic and optical probes for in vivo multimodal imaging sensors.
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spelling pubmed-60914992018-09-25 Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools Materia, Maria Elena Pernia Leal, Manuel Scotto, Marco Balakrishnan, Preethi Bala Kumar Avugadda, Sahitya García-Martín, María L. Cohen, Bruce E. Chan, Emory M. Pellegrino, Teresa Bioconjug Chem [Image: see text] We report the fabrication of aqueous multimodal imaging nanocomposites based on superparamagnetic nanoparticles (MNPs) and two different sizes of photoluminescent upconverting nanoparticles (UCNPs). The controlled and simultaneous incorporation of both types of nanoparticles (NPs) was obtained by controlling the solvent composition and the addition rate of the destabilizing solvent. The magnetic properties of the MNPs remained unaltered after their encapsulation into the polymeric beads as shown by the T2 relaxivity measurements. The UCNPs maintain photoluminescent properties even when embedded with the MNPs into the polymer bead. Moreover, the light emitted by the magnetic and upconverting nanobeads (MUCNBs) under NIR excitation (λ(exc) = 980 nm) was clearly observed through different thicknesses of agarose gel or through a mouse skin layer. The comparison with magnetic and luminescent nanobeads based on red-emitting quantum dots (QDs) demonstrated that while the QD-based beads show significant autofluorescence background from the skin, the signal obtained by the MUCNBs allows a decrease in this background. In summary, these results indicate that MUCNBs are good magnetic and optical probes for in vivo multimodal imaging sensors. American Chemical Society 2017-09-25 2017-11-15 /pmc/articles/PMC6091499/ /pubmed/28945361 http://dx.doi.org/10.1021/acs.bioconjchem.7b00432 Text en Copyright © 2017 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Materia, Maria Elena
Pernia Leal, Manuel
Scotto, Marco
Balakrishnan, Preethi Bala
Kumar Avugadda, Sahitya
García-Martín, María L.
Cohen, Bruce E.
Chan, Emory M.
Pellegrino, Teresa
Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools
title Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools
title_full Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools
title_fullStr Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools
title_full_unstemmed Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools
title_short Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools
title_sort multifunctional magnetic and upconverting nanobeads as dual modal imaging tools
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091499/
https://www.ncbi.nlm.nih.gov/pubmed/28945361
http://dx.doi.org/10.1021/acs.bioconjchem.7b00432
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