The building blocks of successful translation of proteomics to the clinic

Recently, the first two multiplexed tests using selective reaction monitoring (SRM-MS) mass spectrometry have entered clinical practice. Despite different areas of indication, risk stratification in lung cancer and preterm birth, they share multiple steps in their development strategies. Here we rev...

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Detalles Bibliográficos
Autores principales: Kearney, Paul, Boniface, J Jay, Price, Nathan D, Hood, Leroy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091638/
https://www.ncbi.nlm.nih.gov/pubmed/29427919
http://dx.doi.org/10.1016/j.copbio.2017.12.011
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author Kearney, Paul
Boniface, J Jay
Price, Nathan D
Hood, Leroy
author_facet Kearney, Paul
Boniface, J Jay
Price, Nathan D
Hood, Leroy
author_sort Kearney, Paul
collection PubMed
description Recently, the first two multiplexed tests using selective reaction monitoring (SRM-MS) mass spectrometry have entered clinical practice. Despite different areas of indication, risk stratification in lung cancer and preterm birth, they share multiple steps in their development strategies. Here we review these strategies and their implications for successful translation of biomarkers to clinical practice. We believe that the identification of blood protein panels for the identification of disease phenotypes is now a reproducible and standard (albeit complex) process.
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spelling pubmed-60916382018-08-14 The building blocks of successful translation of proteomics to the clinic Kearney, Paul Boniface, J Jay Price, Nathan D Hood, Leroy Curr Opin Biotechnol Article Recently, the first two multiplexed tests using selective reaction monitoring (SRM-MS) mass spectrometry have entered clinical practice. Despite different areas of indication, risk stratification in lung cancer and preterm birth, they share multiple steps in their development strategies. Here we review these strategies and their implications for successful translation of biomarkers to clinical practice. We believe that the identification of blood protein panels for the identification of disease phenotypes is now a reproducible and standard (albeit complex) process. 2018-02-07 2018-06 /pmc/articles/PMC6091638/ /pubmed/29427919 http://dx.doi.org/10.1016/j.copbio.2017.12.011 Text en This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kearney, Paul
Boniface, J Jay
Price, Nathan D
Hood, Leroy
The building blocks of successful translation of proteomics to the clinic
title The building blocks of successful translation of proteomics to the clinic
title_full The building blocks of successful translation of proteomics to the clinic
title_fullStr The building blocks of successful translation of proteomics to the clinic
title_full_unstemmed The building blocks of successful translation of proteomics to the clinic
title_short The building blocks of successful translation of proteomics to the clinic
title_sort building blocks of successful translation of proteomics to the clinic
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091638/
https://www.ncbi.nlm.nih.gov/pubmed/29427919
http://dx.doi.org/10.1016/j.copbio.2017.12.011
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