Cargando…

Effects of preconditioned plasma collected during the late phase of remote ischaemic preconditioning on ventricular arrhythmias caused by myocardial ischaemia reperfusion in rats

OBJECTIVE: The administration of preconditioned plasma collected during the late phase of preconditioning has been shown to reduce myocardial infarct size. This study aimed to investigate if preconditioned plasma could attenuate ventricular arrhythmias in a rat model in vivo. METHODS: Eighty rats we...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Yang, Zheng, Zhi-Nan, Liu, Xiang, Dai, Gang, Jin, San-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091815/
https://www.ncbi.nlm.nih.gov/pubmed/29436250
http://dx.doi.org/10.1177/0300060518755268
_version_ 1783347431366197248
author Zhao, Yang
Zheng, Zhi-Nan
Liu, Xiang
Dai, Gang
Jin, San-Qing
author_facet Zhao, Yang
Zheng, Zhi-Nan
Liu, Xiang
Dai, Gang
Jin, San-Qing
author_sort Zhao, Yang
collection PubMed
description OBJECTIVE: The administration of preconditioned plasma collected during the late phase of preconditioning has been shown to reduce myocardial infarct size. This study aimed to investigate if preconditioned plasma could attenuate ventricular arrhythmias in a rat model in vivo. METHODS: Eighty rats were randomized to eight groups (10 rats/group). Two groups provided preconditioned or non-preconditioned plasma 48 h after transient limb ischaemia or the control protocol. Six groups of ischaemia-reperfusion (IR) rats received normal saline, non-preconditioned plasma, or preconditioned plasma, respectively, 1 h (groups A1, A2, A3) or 24 h (groups B1, B2, B3) before undergoing myocardial IR. Electrocardiograms were monitored using a BIOPAC system, and the incidence and duration of ventricular tachycardia (VT) and ventricular fibrillation (VF) were analysed. RESULTS: No significant differences existed in the incidence and duration of VT or VF among groups A1–A3 or in the incidence and duration of VT among groups B1–B3. However, there was a significantly lower incidence and shorter duration of VF in group B3 rats than in group B1 rats. CONCLUSION: Preconditioned plasma collected during the late phase of preconditioning can reduce the incidence and duration of VF compared with normal saline, suggesting its anti-arrhythmic potential.
format Online
Article
Text
id pubmed-6091815
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-60918152018-08-17 Effects of preconditioned plasma collected during the late phase of remote ischaemic preconditioning on ventricular arrhythmias caused by myocardial ischaemia reperfusion in rats Zhao, Yang Zheng, Zhi-Nan Liu, Xiang Dai, Gang Jin, San-Qing J Int Med Res Research Reports OBJECTIVE: The administration of preconditioned plasma collected during the late phase of preconditioning has been shown to reduce myocardial infarct size. This study aimed to investigate if preconditioned plasma could attenuate ventricular arrhythmias in a rat model in vivo. METHODS: Eighty rats were randomized to eight groups (10 rats/group). Two groups provided preconditioned or non-preconditioned plasma 48 h after transient limb ischaemia or the control protocol. Six groups of ischaemia-reperfusion (IR) rats received normal saline, non-preconditioned plasma, or preconditioned plasma, respectively, 1 h (groups A1, A2, A3) or 24 h (groups B1, B2, B3) before undergoing myocardial IR. Electrocardiograms were monitored using a BIOPAC system, and the incidence and duration of ventricular tachycardia (VT) and ventricular fibrillation (VF) were analysed. RESULTS: No significant differences existed in the incidence and duration of VT or VF among groups A1–A3 or in the incidence and duration of VT among groups B1–B3. However, there was a significantly lower incidence and shorter duration of VF in group B3 rats than in group B1 rats. CONCLUSION: Preconditioned plasma collected during the late phase of preconditioning can reduce the incidence and duration of VF compared with normal saline, suggesting its anti-arrhythmic potential. SAGE Publications 2018-02-13 2018-04 /pmc/articles/PMC6091815/ /pubmed/29436250 http://dx.doi.org/10.1177/0300060518755268 Text en © The Author(s) 2018 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research Reports
Zhao, Yang
Zheng, Zhi-Nan
Liu, Xiang
Dai, Gang
Jin, San-Qing
Effects of preconditioned plasma collected during the late phase of remote ischaemic preconditioning on ventricular arrhythmias caused by myocardial ischaemia reperfusion in rats
title Effects of preconditioned plasma collected during the late phase of remote ischaemic preconditioning on ventricular arrhythmias caused by myocardial ischaemia reperfusion in rats
title_full Effects of preconditioned plasma collected during the late phase of remote ischaemic preconditioning on ventricular arrhythmias caused by myocardial ischaemia reperfusion in rats
title_fullStr Effects of preconditioned plasma collected during the late phase of remote ischaemic preconditioning on ventricular arrhythmias caused by myocardial ischaemia reperfusion in rats
title_full_unstemmed Effects of preconditioned plasma collected during the late phase of remote ischaemic preconditioning on ventricular arrhythmias caused by myocardial ischaemia reperfusion in rats
title_short Effects of preconditioned plasma collected during the late phase of remote ischaemic preconditioning on ventricular arrhythmias caused by myocardial ischaemia reperfusion in rats
title_sort effects of preconditioned plasma collected during the late phase of remote ischaemic preconditioning on ventricular arrhythmias caused by myocardial ischaemia reperfusion in rats
topic Research Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091815/
https://www.ncbi.nlm.nih.gov/pubmed/29436250
http://dx.doi.org/10.1177/0300060518755268
work_keys_str_mv AT zhaoyang effectsofpreconditionedplasmacollectedduringthelatephaseofremoteischaemicpreconditioningonventriculararrhythmiascausedbymyocardialischaemiareperfusioninrats
AT zhengzhinan effectsofpreconditionedplasmacollectedduringthelatephaseofremoteischaemicpreconditioningonventriculararrhythmiascausedbymyocardialischaemiareperfusioninrats
AT liuxiang effectsofpreconditionedplasmacollectedduringthelatephaseofremoteischaemicpreconditioningonventriculararrhythmiascausedbymyocardialischaemiareperfusioninrats
AT daigang effectsofpreconditionedplasmacollectedduringthelatephaseofremoteischaemicpreconditioningonventriculararrhythmiascausedbymyocardialischaemiareperfusioninrats
AT jinsanqing effectsofpreconditionedplasmacollectedduringthelatephaseofremoteischaemicpreconditioningonventriculararrhythmiascausedbymyocardialischaemiareperfusioninrats