High doses of minocycline may induce delayed activation of microglia in aged rats and thus cannot prevent postoperative cognitive dysfunction

OBJECTIVE: Postoperative cognitive dysfunction (POCD) is common after surgery in elderly patients and is associated with high morbidity. The molecular mechanisms responsible for POCD are unknown. Minocycline, an inhibitor of microglial activation, may be useful in treating and preventing POCD. We ex...

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Detalles Bibliográficos
Autores principales: Li, Wenyao, Chai, Qing, Zhang, Hongwei, Ma, Jing, Xu, Chengfen, Dong, Jifu, Wei, Xianghua, Wang, Zhiyi, Zhang, Kexian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Research Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091817/
https://www.ncbi.nlm.nih.gov/pubmed/29458276
http://dx.doi.org/10.1177/0300060517754032

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