Neuroinflammation and ER-stress are key mechanisms of acute bilirubin toxicity and hearing loss in a mouse model

Hyperbilirubinemia (jaundice) is caused by raised levels of unconjugated bilirubin in the blood. When severe, susceptible brain regions including the cerebellum and auditory brainstem are damaged causing neurological sequelae such as ataxia, hearing loss and kernicterus. The mechanism(s) by which bi...

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Detalles Bibliográficos
Autores principales: Schiavon, Emanuele, Smalley, Joshua L., Newton, Sherylanne, Greig, Nigel H., Forsythe, Ian D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091913/
https://www.ncbi.nlm.nih.gov/pubmed/30106954
http://dx.doi.org/10.1371/journal.pone.0201022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091913/
https://www.ncbi.nlm.nih.gov/pubmed/30106954
http://dx.doi.org/10.1371/journal.pone.0201022

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