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Pigmentation phototype and prostate and breast cancer in a select Spanish population—A Mendelian randomization analysis in the MCC-Spain study
INTRODUCTION: Phototype has been associated with an increased risk of prostate cancer, and it is yet unknown if it is related to other hormone-dependent cancers, such as breast cancer or whether this association could be considered causal. METHODS: We examined the association between the phototype a...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091948/ https://www.ncbi.nlm.nih.gov/pubmed/30106959 http://dx.doi.org/10.1371/journal.pone.0201750 |
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author | Gómez-Acebo, Inés Dierssen-Sotos, Trinidad Palazuelos, Camilo Fernández-Navarro, Pablo Castaño-Vinyals, Gemma Alonso-Molero, Jéssica Urtiaga, Carmen Fernández-Villa, Tania Ardanaz, Eva Rivas-del-Fresno, Manuel Molina-Barceló, Ana Jiménez-Moleón, José-Juan García-Martinez, Lidia Amiano, Pilar Rodriguez-Cundin, Paz Moreno, Víctor Pérez-Gómez, Beatriz Aragonés, Nuria Kogevinas, Manolis Pollán, Marina Llorca, Javier |
author_facet | Gómez-Acebo, Inés Dierssen-Sotos, Trinidad Palazuelos, Camilo Fernández-Navarro, Pablo Castaño-Vinyals, Gemma Alonso-Molero, Jéssica Urtiaga, Carmen Fernández-Villa, Tania Ardanaz, Eva Rivas-del-Fresno, Manuel Molina-Barceló, Ana Jiménez-Moleón, José-Juan García-Martinez, Lidia Amiano, Pilar Rodriguez-Cundin, Paz Moreno, Víctor Pérez-Gómez, Beatriz Aragonés, Nuria Kogevinas, Manolis Pollán, Marina Llorca, Javier |
author_sort | Gómez-Acebo, Inés |
collection | PubMed |
description | INTRODUCTION: Phototype has been associated with an increased risk of prostate cancer, and it is yet unknown if it is related to other hormone-dependent cancers, such as breast cancer or whether this association could be considered causal. METHODS: We examined the association between the phototype and breast and prostate cancers using a Mendelian randomization analysis. We studied 1,738 incident cases of breast cancer and another 817 cases of prostate cancer. To perform a Mendelian randomization analysis on the phototype—cancer relationship, a genetic pigmentation score was required that met the following criteria: (1) the genetic pigmentation score was associated with phototype in controls; (2) the genetic pigmentation score was not associated with confounders in the relationship between phototype and cancer, and (3) the genetic pigmentation score was associated with cancer only through its association with phototype. Once this genetic score is available, the association between genetic pigmentation score and cancer can be identified as the association between phototype and cancer. RESULTS: The association between the genetic pigmentation score and phototype in controls showed that a higher genetic pigmentation score was associated with fair skin, blond hair, blue eyes and the presence of freckles. Applying the Mendelian randomization analysis, we verified that there was no association between the genetic pigmentation score and cancers of the breast and prostate. CONCLUSIONS: Phototype is not associated with breast or prostate cancer. |
format | Online Article Text |
id | pubmed-6091948 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-60919482018-08-30 Pigmentation phototype and prostate and breast cancer in a select Spanish population—A Mendelian randomization analysis in the MCC-Spain study Gómez-Acebo, Inés Dierssen-Sotos, Trinidad Palazuelos, Camilo Fernández-Navarro, Pablo Castaño-Vinyals, Gemma Alonso-Molero, Jéssica Urtiaga, Carmen Fernández-Villa, Tania Ardanaz, Eva Rivas-del-Fresno, Manuel Molina-Barceló, Ana Jiménez-Moleón, José-Juan García-Martinez, Lidia Amiano, Pilar Rodriguez-Cundin, Paz Moreno, Víctor Pérez-Gómez, Beatriz Aragonés, Nuria Kogevinas, Manolis Pollán, Marina Llorca, Javier PLoS One Research Article INTRODUCTION: Phototype has been associated with an increased risk of prostate cancer, and it is yet unknown if it is related to other hormone-dependent cancers, such as breast cancer or whether this association could be considered causal. METHODS: We examined the association between the phototype and breast and prostate cancers using a Mendelian randomization analysis. We studied 1,738 incident cases of breast cancer and another 817 cases of prostate cancer. To perform a Mendelian randomization analysis on the phototype—cancer relationship, a genetic pigmentation score was required that met the following criteria: (1) the genetic pigmentation score was associated with phototype in controls; (2) the genetic pigmentation score was not associated with confounders in the relationship between phototype and cancer, and (3) the genetic pigmentation score was associated with cancer only through its association with phototype. Once this genetic score is available, the association between genetic pigmentation score and cancer can be identified as the association between phototype and cancer. RESULTS: The association between the genetic pigmentation score and phototype in controls showed that a higher genetic pigmentation score was associated with fair skin, blond hair, blue eyes and the presence of freckles. Applying the Mendelian randomization analysis, we verified that there was no association between the genetic pigmentation score and cancers of the breast and prostate. CONCLUSIONS: Phototype is not associated with breast or prostate cancer. Public Library of Science 2018-08-14 /pmc/articles/PMC6091948/ /pubmed/30106959 http://dx.doi.org/10.1371/journal.pone.0201750 Text en © 2018 Gómez-Acebo et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Gómez-Acebo, Inés Dierssen-Sotos, Trinidad Palazuelos, Camilo Fernández-Navarro, Pablo Castaño-Vinyals, Gemma Alonso-Molero, Jéssica Urtiaga, Carmen Fernández-Villa, Tania Ardanaz, Eva Rivas-del-Fresno, Manuel Molina-Barceló, Ana Jiménez-Moleón, José-Juan García-Martinez, Lidia Amiano, Pilar Rodriguez-Cundin, Paz Moreno, Víctor Pérez-Gómez, Beatriz Aragonés, Nuria Kogevinas, Manolis Pollán, Marina Llorca, Javier Pigmentation phototype and prostate and breast cancer in a select Spanish population—A Mendelian randomization analysis in the MCC-Spain study |
title | Pigmentation phototype and prostate and breast cancer in a select Spanish population—A Mendelian randomization analysis in the MCC-Spain study |
title_full | Pigmentation phototype and prostate and breast cancer in a select Spanish population—A Mendelian randomization analysis in the MCC-Spain study |
title_fullStr | Pigmentation phototype and prostate and breast cancer in a select Spanish population—A Mendelian randomization analysis in the MCC-Spain study |
title_full_unstemmed | Pigmentation phototype and prostate and breast cancer in a select Spanish population—A Mendelian randomization analysis in the MCC-Spain study |
title_short | Pigmentation phototype and prostate and breast cancer in a select Spanish population—A Mendelian randomization analysis in the MCC-Spain study |
title_sort | pigmentation phototype and prostate and breast cancer in a select spanish population—a mendelian randomization analysis in the mcc-spain study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091948/ https://www.ncbi.nlm.nih.gov/pubmed/30106959 http://dx.doi.org/10.1371/journal.pone.0201750 |
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