VEGF (Vascular Endothelial Growth Factor) Induces NRP1 (Neuropilin-1) Cleavage via ADAMs (a Disintegrin and Metalloproteinase) 9 and 10 to Generate Novel Carboxy-Terminal NRP1 Fragments That Regulate Angiogenic Signaling

OBJECTIVE—: NRP1(neuropilin-1) acts as a coreceptor for VEGF (vascular endothelial growth factor) with an essential role in angiogenesis. Recent findings suggest that posttranslational proteolytic cleavage of VEGF receptors may be an important mechanism for regulating angiogenesis, but the role of N...

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Detalles Bibliográficos
Autores principales: Mehta, Vedanta, Fields, Laura, Evans, Ian M., Yamaji, Maiko, Pellet-Many, Caroline, Jones, Timothy, Mahmoud, Marwa, Zachary, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Basic Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092111/
https://www.ncbi.nlm.nih.gov/pubmed/29880492
http://dx.doi.org/10.1161/ATVBAHA.118.311118

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