Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection

Antiretroviral therapy (ART) during the earliest stage of acute HIV infection (Fiebig I) might minimize establishment of a latent HIV reservoir and thereby facilitate viremic control after analytical treatment interruption (ATI). We show that 8 participants, who initiated treatment during Fiebig I a...

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Autores principales: Colby, Donn, Trautmann, Lydie, Pinyakorn, Suteeraporn, Leyre, Louise, Pagliuzza, Amelie, Kroon, Eugène, Rolland, Morgane, Takata, Hiroshi, Buranapraditkun, Supranee, Intasan, Jintana, Chomchey, Nitiya, Muir, Roshell, Haddad, Elias K., Tovanabutra, Sodsai, Ubolyam, Sasiwimol, Bolton, Diane L., Fullmer, Brandie A., Gorelick, Robert, Fox, Lawrence, Crowell, Trevor, Trichavaroj, Rapee, O’Connell, Robert, Chomont, Nicolas, Kim, Jerome H., Michael, Nelson L., Robb, Merlin L., Phanuphak, Nittaya, Ananworanich, Jintanat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092240/
https://www.ncbi.nlm.nih.gov/pubmed/29892063
http://dx.doi.org/10.1038/s41591-018-0026-6
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author Colby, Donn
Trautmann, Lydie
Pinyakorn, Suteeraporn
Leyre, Louise
Pagliuzza, Amelie
Kroon, Eugène
Rolland, Morgane
Takata, Hiroshi
Buranapraditkun, Supranee
Intasan, Jintana
Chomchey, Nitiya
Muir, Roshell
Haddad, Elias K.
Tovanabutra, Sodsai
Ubolyam, Sasiwimol
Bolton, Diane L.
Fullmer, Brandie A.
Gorelick, Robert
Fox, Lawrence
Crowell, Trevor
Trichavaroj, Rapee
O’Connell, Robert
Chomont, Nicolas
Kim, Jerome H.
Michael, Nelson L.
Robb, Merlin L.
Phanuphak, Nittaya
Ananworanich, Jintanat
author_facet Colby, Donn
Trautmann, Lydie
Pinyakorn, Suteeraporn
Leyre, Louise
Pagliuzza, Amelie
Kroon, Eugène
Rolland, Morgane
Takata, Hiroshi
Buranapraditkun, Supranee
Intasan, Jintana
Chomchey, Nitiya
Muir, Roshell
Haddad, Elias K.
Tovanabutra, Sodsai
Ubolyam, Sasiwimol
Bolton, Diane L.
Fullmer, Brandie A.
Gorelick, Robert
Fox, Lawrence
Crowell, Trevor
Trichavaroj, Rapee
O’Connell, Robert
Chomont, Nicolas
Kim, Jerome H.
Michael, Nelson L.
Robb, Merlin L.
Phanuphak, Nittaya
Ananworanich, Jintanat
author_sort Colby, Donn
collection PubMed
description Antiretroviral therapy (ART) during the earliest stage of acute HIV infection (Fiebig I) might minimize establishment of a latent HIV reservoir and thereby facilitate viremic control after analytical treatment interruption (ATI). We show that 8 participants, who initiated treatment during Fiebig I and were treated for a median of 2.8 years, all experienced rapid viral load rebound following ATI, indicating that additional strategies are required to control or eradicate HIV.
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spelling pubmed-60922402018-12-11 Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection Colby, Donn Trautmann, Lydie Pinyakorn, Suteeraporn Leyre, Louise Pagliuzza, Amelie Kroon, Eugène Rolland, Morgane Takata, Hiroshi Buranapraditkun, Supranee Intasan, Jintana Chomchey, Nitiya Muir, Roshell Haddad, Elias K. Tovanabutra, Sodsai Ubolyam, Sasiwimol Bolton, Diane L. Fullmer, Brandie A. Gorelick, Robert Fox, Lawrence Crowell, Trevor Trichavaroj, Rapee O’Connell, Robert Chomont, Nicolas Kim, Jerome H. Michael, Nelson L. Robb, Merlin L. Phanuphak, Nittaya Ananworanich, Jintanat Nat Med Article Antiretroviral therapy (ART) during the earliest stage of acute HIV infection (Fiebig I) might minimize establishment of a latent HIV reservoir and thereby facilitate viremic control after analytical treatment interruption (ATI). We show that 8 participants, who initiated treatment during Fiebig I and were treated for a median of 2.8 years, all experienced rapid viral load rebound following ATI, indicating that additional strategies are required to control or eradicate HIV. 2018-06-11 2018-07 /pmc/articles/PMC6092240/ /pubmed/29892063 http://dx.doi.org/10.1038/s41591-018-0026-6 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Colby, Donn
Trautmann, Lydie
Pinyakorn, Suteeraporn
Leyre, Louise
Pagliuzza, Amelie
Kroon, Eugène
Rolland, Morgane
Takata, Hiroshi
Buranapraditkun, Supranee
Intasan, Jintana
Chomchey, Nitiya
Muir, Roshell
Haddad, Elias K.
Tovanabutra, Sodsai
Ubolyam, Sasiwimol
Bolton, Diane L.
Fullmer, Brandie A.
Gorelick, Robert
Fox, Lawrence
Crowell, Trevor
Trichavaroj, Rapee
O’Connell, Robert
Chomont, Nicolas
Kim, Jerome H.
Michael, Nelson L.
Robb, Merlin L.
Phanuphak, Nittaya
Ananworanich, Jintanat
Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection
title Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection
title_full Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection
title_fullStr Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection
title_full_unstemmed Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection
title_short Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection
title_sort rapid hiv rna rebound after antiretroviral treatment interruption in persons durably suppressed in fiebig i acute hiv infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092240/
https://www.ncbi.nlm.nih.gov/pubmed/29892063
http://dx.doi.org/10.1038/s41591-018-0026-6
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