Tmc2 expression partially restores auditory function in a mouse model of DFNB7/B11 deafness caused by loss of Tmc1 function

Mouse Tmc1 and Tmc2 are required for sensory transduction in cochlear and vestibular hair cells. Homozygous Tmc1(∆/∆) mice are deaf, Tmc2(∆/∆) mice have normal hearing, and double homozygous Tmc1(∆/∆); Tmc2(∆/∆) mice have deafness and profound vestibular dysfunction. These phenotypes are consistent...

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Detalles Bibliográficos
Autores principales: Nakanishi, Hiroshi, Kurima, Kiyoto, Pan, Bifeng, Wangemann, Philine, Fitzgerald, Tracy S., Géléoc, Gwenaëlle S., Holt, Jeffrey R., Griffith, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092339/
https://www.ncbi.nlm.nih.gov/pubmed/30108230
http://dx.doi.org/10.1038/s41598-018-29709-8

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