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Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase
Members of the TMEM16/ANO family of membrane proteins are Ca(2+)-activated phospholipid scramblases and/or Cl(−) channels. A membrane-exposed hydrophilic groove in these proteins serves as a shared translocation pathway for ions and lipids. However, the mechanism by which lipids gain access to and p...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092359/ https://www.ncbi.nlm.nih.gov/pubmed/30108217 http://dx.doi.org/10.1038/s41467-018-05724-1 |