The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis

Uncontrolled activation of TGFβ signaling is a common denominator of fibrotic tissue remodeling. Here we characterize the tyrosine phosphatase SHP2 as a molecular checkpoint for TGFβ-induced JAK2/STAT3 signaling and as a potential target for the treatment of fibrosis. TGFβ stimulates the phosphatase...

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Detalles Bibliográficos
Autores principales: Zehender, Ariella, Huang, Jingang, Györfi, Andrea-Hermina, Matei, Alexandru-Emil, Trinh-Minh, Thuong, Xu, Xiaohan, Li, Yi-Nan, Chen, Chih-Wei, Lin, Jianping, Dees, Clara, Beyer, Christian, Gelse, Kolja, Zhang, Zhong-Yin, Bergmann, Christina, Ramming, Andreas, Birchmeier, Walter, Distler, Oliver, Schett, Georg, Distler, Jörg H. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092362/
https://www.ncbi.nlm.nih.gov/pubmed/30108215
http://dx.doi.org/10.1038/s41467-018-05768-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092362/
https://www.ncbi.nlm.nih.gov/pubmed/30108215
http://dx.doi.org/10.1038/s41467-018-05768-3

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