The Activation and Signaling Mechanisms of GPR56/ADGRG1 in Melanoma Cell

Adhesion G protein-coupled receptors (aGPCRs) constitute the second largest GPCR subfamily. GPR56/ADGRG1 is a member of the ADGRG subgroup of aGPCRs. Although GPR56 is best known for its pivotal role in the cerebral cortical development, it is also important for tumor progression. Numerous studies h...

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Detalles Bibliográficos
Autores principales: Huang, Kuan-Yeh, Lin, Hsi-Hsien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092491/
https://www.ncbi.nlm.nih.gov/pubmed/30135857
http://dx.doi.org/10.3389/fonc.2018.00304
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author Huang, Kuan-Yeh
Lin, Hsi-Hsien
author_facet Huang, Kuan-Yeh
Lin, Hsi-Hsien
author_sort Huang, Kuan-Yeh
collection PubMed
description Adhesion G protein-coupled receptors (aGPCRs) constitute the second largest GPCR subfamily. GPR56/ADGRG1 is a member of the ADGRG subgroup of aGPCRs. Although GPR56 is best known for its pivotal role in the cerebral cortical development, it is also important for tumor progression. Numerous studies have revealed that GPR56 is expressed in various cancer types with a role in cancer cell adhesion, migration and metastasis. In a recent study, we found that the immobilized GPR56-specific CG4 antibody enhanced IL-6 production and migration ability of melanoma cells. In this review, we will summarize the current understanding of GPR56 function and discuss the activation and signaling mechanisms of GPR56 in melanoma cells.
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spelling pubmed-60924912018-08-22 The Activation and Signaling Mechanisms of GPR56/ADGRG1 in Melanoma Cell Huang, Kuan-Yeh Lin, Hsi-Hsien Front Oncol Oncology Adhesion G protein-coupled receptors (aGPCRs) constitute the second largest GPCR subfamily. GPR56/ADGRG1 is a member of the ADGRG subgroup of aGPCRs. Although GPR56 is best known for its pivotal role in the cerebral cortical development, it is also important for tumor progression. Numerous studies have revealed that GPR56 is expressed in various cancer types with a role in cancer cell adhesion, migration and metastasis. In a recent study, we found that the immobilized GPR56-specific CG4 antibody enhanced IL-6 production and migration ability of melanoma cells. In this review, we will summarize the current understanding of GPR56 function and discuss the activation and signaling mechanisms of GPR56 in melanoma cells. Frontiers Media S.A. 2018-08-08 /pmc/articles/PMC6092491/ /pubmed/30135857 http://dx.doi.org/10.3389/fonc.2018.00304 Text en Copyright © 2018 Huang and Lin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Huang, Kuan-Yeh
Lin, Hsi-Hsien
The Activation and Signaling Mechanisms of GPR56/ADGRG1 in Melanoma Cell
title The Activation and Signaling Mechanisms of GPR56/ADGRG1 in Melanoma Cell
title_full The Activation and Signaling Mechanisms of GPR56/ADGRG1 in Melanoma Cell
title_fullStr The Activation and Signaling Mechanisms of GPR56/ADGRG1 in Melanoma Cell
title_full_unstemmed The Activation and Signaling Mechanisms of GPR56/ADGRG1 in Melanoma Cell
title_short The Activation and Signaling Mechanisms of GPR56/ADGRG1 in Melanoma Cell
title_sort activation and signaling mechanisms of gpr56/adgrg1 in melanoma cell
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092491/
https://www.ncbi.nlm.nih.gov/pubmed/30135857
http://dx.doi.org/10.3389/fonc.2018.00304
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