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Influence of T Cell Coinhibitory Molecules on CD8(+) Recall Responses

T cell co-signaling molecules play an important role in fine-tuning the strength of T cell activation during many types of immune responses, including infection, cancer, transplant rejection, and autoimmunity. Over the last few decades, intense research into these cosignaling molecules has provided...

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Autores principales: Morris, Anna B., Adams, Layne E., Ford, Mandy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092517/
https://www.ncbi.nlm.nih.gov/pubmed/30135685
http://dx.doi.org/10.3389/fimmu.2018.01810
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author Morris, Anna B.
Adams, Layne E.
Ford, Mandy L.
author_facet Morris, Anna B.
Adams, Layne E.
Ford, Mandy L.
author_sort Morris, Anna B.
collection PubMed
description T cell co-signaling molecules play an important role in fine-tuning the strength of T cell activation during many types of immune responses, including infection, cancer, transplant rejection, and autoimmunity. Over the last few decades, intense research into these cosignaling molecules has provided rich evidence to suggest that cosignaling molecules may be harnessed for the treatment of immune-related diseases. In particular, coinhibitory molecules such as programmed-death 1, 2B4, BTLA, TIGIT, LAG-3, TIM-3, and CTLA-4 inhibit T cell responses by counteracting TCR and costimulatory signals, leading to the inhibition of proliferation and effector function and the downregulation of activation and adhesion molecules at the cell surface. While many reviews have focused on the role of coinhibitory molecules in modifying primary CD8(+) T cell responses, in this review, we will consider the complex role of coinhibitory molecules in altering CD8(+) T cell recall potential. As memory CD8(+) T cell responses are critical for protective memory responses in infection and cancer and contribute to potentially pathogenic memory responses in transplant rejection and autoimmunity, understanding the role of coinhibitory receptor control of memory T cells may illuminate important aspects of therapeutically targeting these pathways.
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spelling pubmed-60925172018-08-22 Influence of T Cell Coinhibitory Molecules on CD8(+) Recall Responses Morris, Anna B. Adams, Layne E. Ford, Mandy L. Front Immunol Immunology T cell co-signaling molecules play an important role in fine-tuning the strength of T cell activation during many types of immune responses, including infection, cancer, transplant rejection, and autoimmunity. Over the last few decades, intense research into these cosignaling molecules has provided rich evidence to suggest that cosignaling molecules may be harnessed for the treatment of immune-related diseases. In particular, coinhibitory molecules such as programmed-death 1, 2B4, BTLA, TIGIT, LAG-3, TIM-3, and CTLA-4 inhibit T cell responses by counteracting TCR and costimulatory signals, leading to the inhibition of proliferation and effector function and the downregulation of activation and adhesion molecules at the cell surface. While many reviews have focused on the role of coinhibitory molecules in modifying primary CD8(+) T cell responses, in this review, we will consider the complex role of coinhibitory molecules in altering CD8(+) T cell recall potential. As memory CD8(+) T cell responses are critical for protective memory responses in infection and cancer and contribute to potentially pathogenic memory responses in transplant rejection and autoimmunity, understanding the role of coinhibitory receptor control of memory T cells may illuminate important aspects of therapeutically targeting these pathways. Frontiers Media S.A. 2018-08-08 /pmc/articles/PMC6092517/ /pubmed/30135685 http://dx.doi.org/10.3389/fimmu.2018.01810 Text en Copyright © 2018 Morris, Adams and Ford. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Morris, Anna B.
Adams, Layne E.
Ford, Mandy L.
Influence of T Cell Coinhibitory Molecules on CD8(+) Recall Responses
title Influence of T Cell Coinhibitory Molecules on CD8(+) Recall Responses
title_full Influence of T Cell Coinhibitory Molecules on CD8(+) Recall Responses
title_fullStr Influence of T Cell Coinhibitory Molecules on CD8(+) Recall Responses
title_full_unstemmed Influence of T Cell Coinhibitory Molecules on CD8(+) Recall Responses
title_short Influence of T Cell Coinhibitory Molecules on CD8(+) Recall Responses
title_sort influence of t cell coinhibitory molecules on cd8(+) recall responses
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092517/
https://www.ncbi.nlm.nih.gov/pubmed/30135685
http://dx.doi.org/10.3389/fimmu.2018.01810
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