NF‐κB activation in astrocytes drives a stage‐specific beneficial neuroimmunological response in ALS

Astrocytes are involved in non‐cell‐autonomous pathogenic cascades in amyotrophic lateral sclerosis (ALS); however, their role is still debated. We show that astrocytic NF‐κB activation drives microglial proliferation and leukocyte infiltration in the SOD1 (G93A) ALS model. This response prolongs th...

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Detalles Bibliográficos
Autores principales: Ouali Alami, Najwa, Schurr, Christine, Olde Heuvel, Florian, Tang, Linyun, Li, Qian, Tasdogan, Alpaslan, Kimbara, Atsushi, Nettekoven, Matthias, Ottaviani, Giorgio, Raposo, Catarina, Röver, Stephan, Rogers‐Evans, Mark, Rothenhäusler, Benno, Ullmer, Christoph, Fingerle, Jürgen, Grether, Uwe, Knuesel, Irene, Boeckers, Tobias M, Ludolph, Albert, Wirth, Thomas, Roselli, Francesco, Baumann, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092622/
https://www.ncbi.nlm.nih.gov/pubmed/29875132
http://dx.doi.org/10.15252/embj.201798697

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