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A temporally dynamic Foxp3 autoregulatory transcriptional circuit controls the effector Treg programme

Regulatory T cells (Treg) are negative regulators of the immune response; however, it is poorly understood whether and how Foxp3 transcription is induced and regulated in the periphery during T‐cell responses. Using Foxp3‐Timer of cell kinetics and activity (Tocky) mice, which report real‐time Foxp3...

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Detalles Bibliográficos
Autores principales: Bending, David, Paduraru, Alina, Ducker, Catherine B, Prieto Martín, Paz, Crompton, Tessa, Ono, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092677/
https://www.ncbi.nlm.nih.gov/pubmed/29991564
http://dx.doi.org/10.15252/embj.201899013