LincU Preserves Naïve Pluripotency by Restricting ERK Activity in Embryonic Stem Cells

Although the functional roles of long noncoding RNAs (lncRNAs) have been increasingly identified, few lncRNAs that control the naïve state of embryonic stem cells (ESCs) are known. Here, we report a naïve-state-associated lncRNA, LincU, which is intrinsically activated by Nanog in mESCs. LincU-defic...

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Detalles Bibliográficos
Autores principales: Jiapaer, Zeyidan, Li, Guoping, Ye, Dan, Bai, Mingliang, Li, Jianguo, Guo, Xudong, Du, Yanhua, Su, Dingwen, Jia, Wenwen, Chen, Wen, Wang, Guiying, Yu, Yangyang, Zhu, Fugui, Wan, Xiaoping, Kang, Jiuhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092693/
https://www.ncbi.nlm.nih.gov/pubmed/30017820
http://dx.doi.org/10.1016/j.stemcr.2018.06.010

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