Status of KRAS in iPSCs Impacts upon Self-Renewal and Differentiation Propensity

Oncogenic KRAS mutations in hematopoietic stem cells cause RAS-associated autoimmune lymphoproliferative syndrome-like disease (RALD). KRAS plays essential roles in stemness maintenance in some types of stem cells. However, its roles in pluripotent stem cells (PSCs) are poorly understood. Here, we i...

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Detalles Bibliográficos
Autores principales: Kubara, Kenji, Yamazaki, Kazuto, Ishihara, Yasuharu, Naruto, Takuya, Lin, Huan-Ting, Nishimura, Ken, Ohtaka, Manami, Nakanishi, Mahito, Ito, Masashi, Tsukahara, Kappei, Morio, Tomohiro, Takagi, Masatoshi, Otsu, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092694/
https://www.ncbi.nlm.nih.gov/pubmed/29983389
http://dx.doi.org/10.1016/j.stemcr.2018.06.008

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