The Zinc Finger Transcription Factor PLAGL2 Enhances Stem Cell Fate and Activates Expression of ASCL2 in Intestinal Epithelial Cells

Intestinal epithelial stem cell (IESC) fate is promoted by two major transcriptional regulators, the TCF4/β-catenin complex and ASCL2, which drive expression of IESC-specific factors, including Lgr5, Ephb2, and Rnf43. Canonical Wnt signaling via TCF4/β-catenin directly transactivates Ascl2, which in...

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Detalles Bibliográficos
Autores principales: Strubberg, Ashlee M., Veronese Paniagua, Daniel A., Zhao, Tingting, Dublin, Leeran, Pritchard, Thomas, Bayguinov, Peter O., Fitzpatrick, James A.J., Madison, Blair B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092695/
https://www.ncbi.nlm.nih.gov/pubmed/30017821
http://dx.doi.org/10.1016/j.stemcr.2018.06.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092695/
https://www.ncbi.nlm.nih.gov/pubmed/30017821
http://dx.doi.org/10.1016/j.stemcr.2018.06.009

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