Cargando…

The Zinc Finger Transcription Factor PLAGL2 Enhances Stem Cell Fate and Activates Expression of ASCL2 in Intestinal Epithelial Cells

Intestinal epithelial stem cell (IESC) fate is promoted by two major transcriptional regulators, the TCF4/β-catenin complex and ASCL2, which drive expression of IESC-specific factors, including Lgr5, Ephb2, and Rnf43. Canonical Wnt signaling via TCF4/β-catenin directly transactivates Ascl2, which in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Strubberg, Ashlee M., Veronese Paniagua, Daniel A., Zhao, Tingting, Dublin, Leeran, Pritchard, Thomas, Bayguinov, Peter O., Fitzpatrick, James A.J., Madison, Blair B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092695/ https://www.ncbi.nlm.nih.gov/pubmed/30017821 http://dx.doi.org/10.1016/j.stemcr.2018.06.009

Ejemplares similares

MicroRNAs in the etiology of colorectal cancer: pathways and clinical implications
por: Strubberg, Ashlee M., et al.
Publicado: (2017)

Amplification of the PLAG-family genes—PLAGL1 and PLAGL2—is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification
por: Keck, Michaela-Kristina, et al.
Publicado: (2022)

Correction to: Amplification of the PLAG-family genes—PLAGL1 and PLAGL2—is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification
por: Keck, Michaela-Kristina, et al.
Publicado: (2023)

The PLAGL2/MYCN/miR-506-3p interplay regulates neuroblastoma cell fate and associates with neuroblastoma progression
por: Zhao, Zhenze, et al.
Publicado: (2020)

OTHR-41. Amplification of the PLAG family genes – PLAGL1 and PLAGL2 – is a key feature of a novel embryonal CNS tumor type
por: Keck, Michaela-Kristina, et al.
Publicado: (2022)

Ascl1b and Neurod1, instead of Neurog3, control pancreatic endocrine cell fate in zebrafish
por: Flasse, Lydie C, et al.
Publicado: (2013)

PLAGL1 gene function during hepatoma cells proliferation
por: Vega-Benedetti, Ana F., et al.
Publicado: (2018)

PLAGL1 is associated with prognosis and cell proliferation in pancreatic adenocarcinoma
por: Liang, Xing, et al.
Publicado: (2023)

Zinc Finger Database (ZiFDB): a repository for information on C2H2 zinc fingers and engineered zinc-finger arrays
por: Fu, Fengli, et al.
Publicado: (2009)

Plag1 and Plagl2 have overlapping and distinct functions in telencephalic development
por: Adnani, Lata, et al.
Publicado: (2018)

High Expression of PLAGL2 is Associated With Poor Prognosis in High-Grade Glioma
por: Wang, Gang, et al.
Publicado: (2022)

Introducing the Stem Cell ASCL2 Reporter STAR into Intestinal Organoids
por: Heinz, Maria C., et al.
Publicado: (2020)

Zinc Finger Database (ZiFDB) v2.0: a comprehensive database of C(2)H(2) zinc fingers and engineered zinc finger arrays
por: Fu, Fengli, et al.
Publicado: (2013)

The PlagL2 transcription factor activates Mpl transcription and signaling in hematopoietic progenitor and leukemia cells
por: Landrette, Sean F, et al.
Publicado: (2011)

Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity
por: Kaise, Takashi, et al.
Publicado: (2022)

Transcription factor ASCL2 is required for development of the glycogen trophoblast cell lineage
por: Bogutz, Aaron B., et al.
Publicado: (2018)

Zymosan-A promotes the regeneration of intestinal stem cells by upregulating ASCL2
por: Du, Jicong, et al.
Publicado: (2022)

The N terminus of Ascl1 underlies differing proneural activity of mouse and Xenopus Ascl1 proteins
por: Hardwick, Laura J.A., et al.
Publicado: (2018)

Involvement of PLAGL1/ZAC1 in hypocretin/orexin transcription
por: Tanaka, Susumu, et al.
Publicado: (2019)

Expression of PLAGL2 in bladder urothelial carcinoma and its relationship to lymph node metastasis and survival
por: Qu, Genyi, et al.
Publicado: (2018)

Overexpressed PLAGL2 transcriptionally activates Wnt6 and promotes cancer development in colorectal cancer
por: Li, Nanpeng, et al.
Publicado: (2019)

Increased miR-214 expression suppresses cell migration and proliferation in Hirschsprung disease by interacting with PLAGL2
por: Wu, Liang, et al.
Publicado: (2019)

A21 OVEREXPRESSION OF ASCL2 ALTERS DIFFERENTIATION IN ESOPHAGEAL ORGANOIDS
por: Hamilton, M, et al.
Publicado: (2022)

ASCL1 phosphorylation and ID2 upregulation are roadblocks to glioblastoma stem cell differentiation
por: Azzarelli, Roberta, et al.
Publicado: (2022)

Transcription Factor PLAGL1 Is Associated with Angiogenic Gene Expression in the Placenta
por: Starks, Rebekah R., et al.
Publicado: (2020)

Genomic Imprinting at the Porcine PLAGL1 Locus and the Orthologous Locus in the Human
por: Ahn, Jinsoo, et al.
Publicado: (2021)

PLAGL2 promotes the proliferation and migration of gastric cancer cells via USP37-mediated deubiquitination of Snail1
por: Wu, Liang, et al.
Publicado: (2021)

METTL14 Regulates PLAGL2/β-Catenin Signaling Axis to Promote the Development of Nonsmall Cell Lung Cancer
por: Zhou, Qianhui, et al.
Publicado: (2023)

Intestinal Stem Cell Marker ASCL2 is a Novel Prognostic Predictor in Esophageal Adenocarcinoma
por: Shibahara, Yukiko, et al.
Publicado: (2022)

ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool
por: Sander, Jeffry D., et al.
Publicado: (2010)

Studying the mechanism of PLAGL2 overexpression and its carcinogenic characteristics based on 3′-untranslated region in colorectal cancer
por: Su, Chen, et al.
Publicado: (2018)

DJ-1 promotes colorectal cancer progression through activating PLAGL2/Wnt/BMP4 axis
por: Zhou, Jing, et al.
Publicado: (2018)

Zinc finger structure determination by NMR: Why zinc fingers can be a handful
por: Neuhaus, David
Publicado: (2022)

Evolution of C2H2-zinc finger genes revisited
por: Thomas, James H, et al.
Publicado: (2009)

In-depth study of DNA binding of Cys(2)His(2) finger domains in testis zinc-finger protein
por: Chou, Chun-Chi, et al.
Publicado: (2017)

Generation of Induced Neuronal Cells by the Single Reprogramming Factor ASCL1
por: Chanda, Soham, et al.
Publicado: (2014)

Epigenetic Editing of Ascl1 Gene in Neural Stem Cells by Optogenetics
por: Lo, Chiao-Ling, et al.
Publicado: (2017)

Specific Labeling of Stem Cell Activity in Human Colorectal Organoids Using an ASCL2-Responsive Minigene
por: Oost, Koen C., et al.
Publicado: (2018)

TNFα-induced Up-regulation of Ascl2 Affects the Differentiation and Proliferation of Neural Stem Cells
por: Liu, Zhongfeng, et al.
Publicado: (2019)

ASCL2 Affects the Efficacy of Immunotherapy in Colon Adenocarcinoma Based on Single-Cell RNA Sequencing Analysis
por: Wu, Lei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vn56stdk0udiev7gccqr8h0re0