Optimal Hypoxia Regulates Human iPSC-Derived Liver Bud Differentiation through Intercellular TGFB Signaling

Timely controlled oxygen (O(2)) delivery is crucial for the developing liver. However, the influence of O(2) on intercellular communication during hepatogenesis is unclear. Using a human induced pluripotent stem cell-derived liver bud (hiPSC-LB) model, we found hypoxia induced with an O(2)-permeable...

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Detalles Bibliográficos
Autores principales: Ayabe, Hiroaki, Anada, Takahisa, Kamoya, Takuo, Sato, Tomoya, Kimura, Masaki, Yoshizawa, Emi, Kikuchi, Shunyuu, Ueno, Yasuharu, Sekine, Keisuke, Camp, J. Gray, Treutlein, Barbara, Ferguson, Autumn, Suzuki, Osamu, Takebe, Takanori, Taniguchi, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092760/
https://www.ncbi.nlm.nih.gov/pubmed/30033085
http://dx.doi.org/10.1016/j.stemcr.2018.06.015

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