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CRISPR-SKIP: programmable gene splicing with single base editors

CRISPR gene editing has revolutionized biomedicine and biotechnology by providing a simple means to engineer genes through targeted double-strand breaks in the genomic DNA of living cells. However, given the stochasticity of cellular DNA repair mechanisms and the potential for off-target mutations,...

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Detalles Bibliográficos
Autores principales:	Gapinske, Michael, Luu, Alan, Winter, Jackson, Woods, Wendy S., Kostan, Kurt A., Shiva, Nikhil, Song, Jun S., Perez-Pinera, Pablo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Method
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092781/ https://www.ncbi.nlm.nih.gov/pubmed/30107853 http://dx.doi.org/10.1186/s13059-018-1482-5

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