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Synchronous birth is a dominant pattern in receptor-ligand evolution
BACKGROUND: Interactions between proteins are key components in the chemical and physical processes of living organisms. Among these interactions, membrane receptors and their ligands are particularly important because they are at the interface between extracellular and intracellular environments. M...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092800/ https://www.ncbi.nlm.nih.gov/pubmed/30107779 http://dx.doi.org/10.1186/s12864-018-4977-2 |
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author | Grandchamp, Anna Monget, Philippe |
author_facet | Grandchamp, Anna Monget, Philippe |
author_sort | Grandchamp, Anna |
collection | PubMed |
description | BACKGROUND: Interactions between proteins are key components in the chemical and physical processes of living organisms. Among these interactions, membrane receptors and their ligands are particularly important because they are at the interface between extracellular and intracellular environments. Many studies have investigated how binding partners have co-evolved in genomes during the evolution. However, little is known about the establishment of the interaction on a phylogenetic scale. In this study, we systematically studied the time of birth of genes encoding human membrane receptors and their ligands in the animal tree of life. We examined a total of 553 pairs of ligands/receptors, representing non-redundant interactions. RESULTS: We found that 41% of the receptors and their respective first ligands appeared in the same branch, representing 2.5-fold more than expected by chance, thus suggesting an evolutionary dynamic of interdependence and conservation between these partners. In contrast, 21% of the receptors appeared after their ligand, i.e. three-fold less often than expected by chance. Most surprisingly, 38% of the receptors appeared before their first ligand, as much as expected by chance. CONCLUSIONS: According to these results, we propose that a selective pressure is exerted on ligands and receptors once they appear, that would remove molecules whose partner does not appear quickly. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12864-018-4977-2) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6092800 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-60928002018-08-20 Synchronous birth is a dominant pattern in receptor-ligand evolution Grandchamp, Anna Monget, Philippe BMC Genomics Research Article BACKGROUND: Interactions between proteins are key components in the chemical and physical processes of living organisms. Among these interactions, membrane receptors and their ligands are particularly important because they are at the interface between extracellular and intracellular environments. Many studies have investigated how binding partners have co-evolved in genomes during the evolution. However, little is known about the establishment of the interaction on a phylogenetic scale. In this study, we systematically studied the time of birth of genes encoding human membrane receptors and their ligands in the animal tree of life. We examined a total of 553 pairs of ligands/receptors, representing non-redundant interactions. RESULTS: We found that 41% of the receptors and their respective first ligands appeared in the same branch, representing 2.5-fold more than expected by chance, thus suggesting an evolutionary dynamic of interdependence and conservation between these partners. In contrast, 21% of the receptors appeared after their ligand, i.e. three-fold less often than expected by chance. Most surprisingly, 38% of the receptors appeared before their first ligand, as much as expected by chance. CONCLUSIONS: According to these results, we propose that a selective pressure is exerted on ligands and receptors once they appear, that would remove molecules whose partner does not appear quickly. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12864-018-4977-2) contains supplementary material, which is available to authorized users. BioMed Central 2018-08-14 /pmc/articles/PMC6092800/ /pubmed/30107779 http://dx.doi.org/10.1186/s12864-018-4977-2 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Grandchamp, Anna Monget, Philippe Synchronous birth is a dominant pattern in receptor-ligand evolution |
title | Synchronous birth is a dominant pattern in receptor-ligand evolution |
title_full | Synchronous birth is a dominant pattern in receptor-ligand evolution |
title_fullStr | Synchronous birth is a dominant pattern in receptor-ligand evolution |
title_full_unstemmed | Synchronous birth is a dominant pattern in receptor-ligand evolution |
title_short | Synchronous birth is a dominant pattern in receptor-ligand evolution |
title_sort | synchronous birth is a dominant pattern in receptor-ligand evolution |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092800/ https://www.ncbi.nlm.nih.gov/pubmed/30107779 http://dx.doi.org/10.1186/s12864-018-4977-2 |
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