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Rabies virus transmission via solid organs or tissue allotransplantation
BACKGROUND: Rabies, for which the mortality rate is almost 100%, is a zoonotic viral disease that can be transmitted via solid organs or tissue allotransplantation. Dozens of deaths from rabies via solid organs or tissues allotransplantation (ROTA) have been documented during the last decades. In 20...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092857/ https://www.ncbi.nlm.nih.gov/pubmed/30107857 http://dx.doi.org/10.1186/s40249-018-0467-7 |
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author | Lu, Xue-Xin Zhu, Wu-Yang Wu, Gui-Zhen |
author_facet | Lu, Xue-Xin Zhu, Wu-Yang Wu, Gui-Zhen |
author_sort | Lu, Xue-Xin |
collection | PubMed |
description | BACKGROUND: Rabies, for which the mortality rate is almost 100%, is a zoonotic viral disease that can be transmitted via solid organs or tissue allotransplantation. Dozens of deaths from rabies via solid organs or tissues allotransplantation (ROTA) have been documented during the last decades. In 2015 and 2016, two cases of rabies virus transmission via solid organs or tissue allotransplantation were reported in China, which further underscore the risk and importance of this special type of rabies for organ transplant recipients. MAIN TEXT: From 1978 to 2017, at least 13 cases of ROTA, causing dozens of deaths, have been reported worldwide, whether in the high-risk or low-risk countries of rabies. The reported incubation period of ROTA ranges from 11 days to more than 17 months, while the historical incubation period of rabies is generally considered to range from ~ 1 week to several years. The pathogenesis of ROTA is not clear, but the use of post-exposure prophylaxis (PEP) can play a protective role in the transplant recipients. We also summarize reports about ROTA in China, combined with the actual situation regarding work on rabies surveillance and elimination, and suggest countermeasures for the prevention and control of ROTA in the future. CONCLUSIONS: Understanding the significance of ROTA, screening the suspected organs, assessing the risk and protecting the related population will be effective way to prevent and control further occurrence of ROTA. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40249-018-0467-7) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6092857 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-60928572018-08-20 Rabies virus transmission via solid organs or tissue allotransplantation Lu, Xue-Xin Zhu, Wu-Yang Wu, Gui-Zhen Infect Dis Poverty Scoping Review BACKGROUND: Rabies, for which the mortality rate is almost 100%, is a zoonotic viral disease that can be transmitted via solid organs or tissue allotransplantation. Dozens of deaths from rabies via solid organs or tissues allotransplantation (ROTA) have been documented during the last decades. In 2015 and 2016, two cases of rabies virus transmission via solid organs or tissue allotransplantation were reported in China, which further underscore the risk and importance of this special type of rabies for organ transplant recipients. MAIN TEXT: From 1978 to 2017, at least 13 cases of ROTA, causing dozens of deaths, have been reported worldwide, whether in the high-risk or low-risk countries of rabies. The reported incubation period of ROTA ranges from 11 days to more than 17 months, while the historical incubation period of rabies is generally considered to range from ~ 1 week to several years. The pathogenesis of ROTA is not clear, but the use of post-exposure prophylaxis (PEP) can play a protective role in the transplant recipients. We also summarize reports about ROTA in China, combined with the actual situation regarding work on rabies surveillance and elimination, and suggest countermeasures for the prevention and control of ROTA in the future. CONCLUSIONS: Understanding the significance of ROTA, screening the suspected organs, assessing the risk and protecting the related population will be effective way to prevent and control further occurrence of ROTA. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40249-018-0467-7) contains supplementary material, which is available to authorized users. BioMed Central 2018-08-15 /pmc/articles/PMC6092857/ /pubmed/30107857 http://dx.doi.org/10.1186/s40249-018-0467-7 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Scoping Review Lu, Xue-Xin Zhu, Wu-Yang Wu, Gui-Zhen Rabies virus transmission via solid organs or tissue allotransplantation |
title | Rabies virus transmission via solid organs or tissue allotransplantation |
title_full | Rabies virus transmission via solid organs or tissue allotransplantation |
title_fullStr | Rabies virus transmission via solid organs or tissue allotransplantation |
title_full_unstemmed | Rabies virus transmission via solid organs or tissue allotransplantation |
title_short | Rabies virus transmission via solid organs or tissue allotransplantation |
title_sort | rabies virus transmission via solid organs or tissue allotransplantation |
topic | Scoping Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092857/ https://www.ncbi.nlm.nih.gov/pubmed/30107857 http://dx.doi.org/10.1186/s40249-018-0467-7 |
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