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Understanding depression in type 2 diabetes: a biological approach in observational studies

Depression is twice as common in type 2 diabetes as in the general population and is associated with adverse health outcomes. Growing evidence suggest that type 2 diabetes and depression share biological mechanisms. This brief commentary discusses current understanding of shared biological pathways,...

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Autores principales: van Sloten, Thomas, Schram, Miranda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092903/
https://www.ncbi.nlm.nih.gov/pubmed/30135724
http://dx.doi.org/10.12688/f1000research.13898.1
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author van Sloten, Thomas
Schram, Miranda
author_facet van Sloten, Thomas
Schram, Miranda
author_sort van Sloten, Thomas
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description Depression is twice as common in type 2 diabetes as in the general population and is associated with adverse health outcomes. Growing evidence suggest that type 2 diabetes and depression share biological mechanisms. This brief commentary discusses current understanding of shared biological pathways, focussing on hyperglycaemia, (micro)vascular dysfunction, and low-grade inflammation. Although there is accumulating evidence that these pathways are involved in the link between type 2 diabetes and depression, direct evidence of their temporal associations is lacking because of a paucity of longitudinal studies that focus on the pathobiology of both type 2 diabetes and depression.
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spelling pubmed-60929032018-08-21 Understanding depression in type 2 diabetes: a biological approach in observational studies van Sloten, Thomas Schram, Miranda F1000Res Review Depression is twice as common in type 2 diabetes as in the general population and is associated with adverse health outcomes. Growing evidence suggest that type 2 diabetes and depression share biological mechanisms. This brief commentary discusses current understanding of shared biological pathways, focussing on hyperglycaemia, (micro)vascular dysfunction, and low-grade inflammation. Although there is accumulating evidence that these pathways are involved in the link between type 2 diabetes and depression, direct evidence of their temporal associations is lacking because of a paucity of longitudinal studies that focus on the pathobiology of both type 2 diabetes and depression. F1000 Research Limited 2018-08-14 /pmc/articles/PMC6092903/ /pubmed/30135724 http://dx.doi.org/10.12688/f1000research.13898.1 Text en Copyright: © 2018 van Sloten T and Schram M http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
van Sloten, Thomas
Schram, Miranda
Understanding depression in type 2 diabetes: a biological approach in observational studies
title Understanding depression in type 2 diabetes: a biological approach in observational studies
title_full Understanding depression in type 2 diabetes: a biological approach in observational studies
title_fullStr Understanding depression in type 2 diabetes: a biological approach in observational studies
title_full_unstemmed Understanding depression in type 2 diabetes: a biological approach in observational studies
title_short Understanding depression in type 2 diabetes: a biological approach in observational studies
title_sort understanding depression in type 2 diabetes: a biological approach in observational studies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092903/
https://www.ncbi.nlm.nih.gov/pubmed/30135724
http://dx.doi.org/10.12688/f1000research.13898.1
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