Genetically Engineered iPSC-Derived FTDP-17 MAPT Neurons Display Mutation-Specific Neurodegenerative and Neurodevelopmental Phenotypes

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Tauopathies such as frontotemporal dementia (FTD) remain incurable to date, partially due to the lack of translational in vitro disease models. The MAPT gene, encoding the microtubule-associated protein tau, has been shown to play an important role in FTD pathogenesis. Therefore, we used zinc finger...

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Detalles Bibliográficos
Autores principales: Verheyen, An, Diels, Annick, Reumers, Joke, Van Hoorde, Kirsten, Van den Wyngaert, Ilse, van Outryve d’Ydewalle, Constantin, De Bondt, An, Kuijlaars, Jacobine, De Muynck, Louis, De Hoogt, Ronald, Bretteville, Alexis, Jaensch, Steffen, Buist, Arjan, Cabrera-Socorro, Alfredo, Wray, Selina, Ebneth, Andreas, Roevens, Peter, Royaux, Ines, Peeters, Pieter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093179/
https://www.ncbi.nlm.nih.gov/pubmed/30057263
http://dx.doi.org/10.1016/j.stemcr.2018.06.022

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