Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease

Atopic dermatitis (AD) is a chronic inflammatory skin disease where more than 90% of patients affected are colonized with Staphylococcus aureus. In AD, S. aureus δ-toxin is a major virulence factor causing cutaneous inflammation via mast cell degranulation. δ-toxin is controlled by the S. aureus agr...

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Autores principales: Baldry, Mara, Nakamura, Yuumi, Nakagawa, Seitaro, Frees, Dorte, Matsue, Hiroyuki, Núñez, Gabriel, Ingmer, Hanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093339/
https://www.ncbi.nlm.nih.gov/pubmed/29733353
http://dx.doi.org/10.1093/infdis/jiy259
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author Baldry, Mara
Nakamura, Yuumi
Nakagawa, Seitaro
Frees, Dorte
Matsue, Hiroyuki
Núñez, Gabriel
Ingmer, Hanne
author_facet Baldry, Mara
Nakamura, Yuumi
Nakagawa, Seitaro
Frees, Dorte
Matsue, Hiroyuki
Núñez, Gabriel
Ingmer, Hanne
author_sort Baldry, Mara
collection PubMed
description Atopic dermatitis (AD) is a chronic inflammatory skin disease where more than 90% of patients affected are colonized with Staphylococcus aureus. In AD, S. aureus δ-toxin is a major virulence factor causing cutaneous inflammation via mast cell degranulation. δ-toxin is controlled by the S. aureus agr quorum sensing system, and thus we addressed whether interference with agr signaling would limit skin inflammation. Indeed, treatment of S. aureus with the agr-inhibitor solonamide B (SolB) abolished δ-toxin production and reduced skin inflammation in a mouse model of inflammatory skin disease, demonstrating the potential of antivirulence therapy in treating S. aureus-induced skin disorders.
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spelling pubmed-60933392018-08-22 Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease Baldry, Mara Nakamura, Yuumi Nakagawa, Seitaro Frees, Dorte Matsue, Hiroyuki Núñez, Gabriel Ingmer, Hanne J Infect Dis Major Articles and Brief Reports Atopic dermatitis (AD) is a chronic inflammatory skin disease where more than 90% of patients affected are colonized with Staphylococcus aureus. In AD, S. aureus δ-toxin is a major virulence factor causing cutaneous inflammation via mast cell degranulation. δ-toxin is controlled by the S. aureus agr quorum sensing system, and thus we addressed whether interference with agr signaling would limit skin inflammation. Indeed, treatment of S. aureus with the agr-inhibitor solonamide B (SolB) abolished δ-toxin production and reduced skin inflammation in a mouse model of inflammatory skin disease, demonstrating the potential of antivirulence therapy in treating S. aureus-induced skin disorders. Oxford University Press 2018-09-15 2018-05-04 /pmc/articles/PMC6093339/ /pubmed/29733353 http://dx.doi.org/10.1093/infdis/jiy259 Text en © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Major Articles and Brief Reports
Baldry, Mara
Nakamura, Yuumi
Nakagawa, Seitaro
Frees, Dorte
Matsue, Hiroyuki
Núñez, Gabriel
Ingmer, Hanne
Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease
title Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease
title_full Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease
title_fullStr Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease
title_full_unstemmed Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease
title_short Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease
title_sort application of an agr-specific antivirulence compound as therapy for staphylococcus aureus-induced inflammatory skin disease
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093339/
https://www.ncbi.nlm.nih.gov/pubmed/29733353
http://dx.doi.org/10.1093/infdis/jiy259
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