Directional Porin Binding of Intrinsically Disordered Protein Sequences Promotes Colicin Epitope Display in the Bacterial Periplasm

[Image: see text] Protein bacteriocins are potent narrow spectrum antibiotics that exploit outer membrane porins to kill bacteria by poorly understood mechanisms. Here, we determine how colicins, bacteriocins specific for Escherichia coli, engage the trimeric porin OmpF to initiate toxin entry. The...

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Detalles Bibliográficos
Autores principales: Housden, Nicholas G., Rassam, Patrice, Lee, Sejeong, Samsudin, Firdaus, Kaminska, Renata, Sharp, Connor, Goult, Jonathan D., Francis, Marie-Louise, Khalid, Syma, Bayley, Hagan, Kleanthous, Colin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093495/
https://www.ncbi.nlm.nih.gov/pubmed/29949342
http://dx.doi.org/10.1021/acs.biochem.8b00621

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