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Multinucleotide mutations cause false inferences of lineage-specific positive selection
Phylogenetic tests of adaptive evolution, such as the widely used branch-site test, assume that nucleotide substitutions occur singly and independently. But recent research has shown that errors at adjacent sites often occur during DNA replication, and the resulting multinucleotide mutations (MNMs)...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093625/ https://www.ncbi.nlm.nih.gov/pubmed/29967485 http://dx.doi.org/10.1038/s41559-018-0584-5 |