A VP1 mutation acquired during an enterovirus 71 disseminated infection confers heparan sulfate binding ability and modulates ex vivo tropism

Enterovirus 71 (EV71) causes hand, foot and mouth disease, a mild and self-limited illness that is sometimes associated with severe neurological complications. EV71 neurotropic determinants remain ill-defined to date. We previously identified a mutation in the VP1 capsid protein (L97R) that was acqu...

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Detalles Bibliográficos
Autores principales: Tseligka, Eirini D., Sobo, Komla, Stoppini, Luc, Cagno, Valeria, Abdul, Fabien, Piuz, Isabelle, Meylan, Pascal, Huang, Song, Constant, Samuel, Tapparel, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093697/
https://www.ncbi.nlm.nih.gov/pubmed/30075025
http://dx.doi.org/10.1371/journal.ppat.1007190

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