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Factor XII Deficiency Mimicking Bleeding Diathesis: A Unique Presentation and Diagnostic Pitfall
Factor XII (FXII), also known as Hageman factor, is a coagulation protein that is necessary for the functioning of the intrinsic coagulation cascade and fibrin formation. When deficient, it results in a significant prolongation of activated partial thromboplastin time (aPTT), mimicking a bleeding di...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093754/ https://www.ncbi.nlm.nih.gov/pubmed/30128221 http://dx.doi.org/10.7759/cureus.2817 |
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author | Fernandes, Hermina D Newton, Shauna Rodrigues, Jonathan M |
author_facet | Fernandes, Hermina D Newton, Shauna Rodrigues, Jonathan M |
author_sort | Fernandes, Hermina D |
collection | PubMed |
description | Factor XII (FXII), also known as Hageman factor, is a coagulation protein that is necessary for the functioning of the intrinsic coagulation cascade and fibrin formation. When deficient, it results in a significant prolongation of activated partial thromboplastin time (aPTT), mimicking a bleeding disorder. However, it does not result in clinical bleeding tendency. We report a case of an elderly male who was found to have prolonged aPTT, discovered during preoperative evaluation for operative repair of hip fracture. Although laboratory investigation was suggestive of bleeding tendency, he was diagnosed with factor XII deficiency and had no bleeding complications intra-operatively or in the post-operative period. |
format | Online Article Text |
id | pubmed-6093754 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-60937542018-08-20 Factor XII Deficiency Mimicking Bleeding Diathesis: A Unique Presentation and Diagnostic Pitfall Fernandes, Hermina D Newton, Shauna Rodrigues, Jonathan M Cureus Internal Medicine Factor XII (FXII), also known as Hageman factor, is a coagulation protein that is necessary for the functioning of the intrinsic coagulation cascade and fibrin formation. When deficient, it results in a significant prolongation of activated partial thromboplastin time (aPTT), mimicking a bleeding disorder. However, it does not result in clinical bleeding tendency. We report a case of an elderly male who was found to have prolonged aPTT, discovered during preoperative evaluation for operative repair of hip fracture. Although laboratory investigation was suggestive of bleeding tendency, he was diagnosed with factor XII deficiency and had no bleeding complications intra-operatively or in the post-operative period. Cureus 2018-06-15 /pmc/articles/PMC6093754/ /pubmed/30128221 http://dx.doi.org/10.7759/cureus.2817 Text en Copyright © 2018, Fernandes et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Fernandes, Hermina D Newton, Shauna Rodrigues, Jonathan M Factor XII Deficiency Mimicking Bleeding Diathesis: A Unique Presentation and Diagnostic Pitfall |
title | Factor XII Deficiency Mimicking Bleeding Diathesis: A Unique Presentation and Diagnostic Pitfall |
title_full | Factor XII Deficiency Mimicking Bleeding Diathesis: A Unique Presentation and Diagnostic Pitfall |
title_fullStr | Factor XII Deficiency Mimicking Bleeding Diathesis: A Unique Presentation and Diagnostic Pitfall |
title_full_unstemmed | Factor XII Deficiency Mimicking Bleeding Diathesis: A Unique Presentation and Diagnostic Pitfall |
title_short | Factor XII Deficiency Mimicking Bleeding Diathesis: A Unique Presentation and Diagnostic Pitfall |
title_sort | factor xii deficiency mimicking bleeding diathesis: a unique presentation and diagnostic pitfall |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093754/ https://www.ncbi.nlm.nih.gov/pubmed/30128221 http://dx.doi.org/10.7759/cureus.2817 |
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