Low frequency cortical activity is a neuromodulatory target that tracks recovery after stroke

Recent work has highlighted the importance of transient low-frequency oscillatory (LFO, < 4 Hz) activity in the healthy motor cortex (M1) during skilled upper-limb tasks. These brief bouts of oscillatory activity may establish the timing or sequencing of motor actions. Here we show that LFOs track motor recovery post-stroke and can be a physiological target for neuromodulation. In rodents, we found that reach-related LFOs, as measured in both the LFP and related spiking activity, were diminished after stroke and that spontaneous recovery was closely correlated with their restoration in perilesional cortex. Sensorimotor LFOs were also diminished in a human subject with chronic disability after stroke in contrast to two non-stroke subjects who demonstrated robust LFOs. Therapeutic delivery of electrical stimulation time-locked to the expected onset of LFOs was found to significantly improve skilled reaching in stroke animals. Together, our results suggest that restoration or modulation of cortical oscillatory dynamics is important for recovery of upper-limb function and that they may serve as a novel target for clinical neuromodulation.