Purkinje cells derived from TSC patients display hypoexcitability and synaptic deficits associated with reduced FMRP levels and reversed by rapamycin

Accumulating evidence suggests that cerebellar dysfunction early in life is associated with autism spectrum disorder (ASD), but the molecular mechanisms underlying the cerebellar deficits at the cellular level are unclear. Tuberous sclerosis complex (TSC) is a neurocutaneous disorder that often pres...

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Detalles Bibliográficos
Autores principales: Sundberg, Maria, Tochitsky, Ivan, Buchholz, David E., Winden, Kellen, Kujala, Ville, Kapur, Kush, Cataltepe, Deniz, Turner, Daria, Han, Min-Joon, Woolf, Clifford J., Hatten, Mary E., Sahin, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093816/
https://www.ncbi.nlm.nih.gov/pubmed/29449635
http://dx.doi.org/10.1038/s41380-018-0018-4

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