Mapt deletion fails to rescue premature lethality in two models of sodium channel epilepsy

Deletion of Mapt, encoding the microtubule‐binding protein Tau, prevents disease in multiple genetic models of hyperexcitability. To investigate whether the effect of Tau depletion is generalizable across multiple sodium channel gene‐linked models of epilepsy, we examined the Scn1b (−/−) mouse model...

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Detalles Bibliográficos
Autores principales: Chen, Chunling, Holth, Jerrah K., Bunton‐Stasyshyn, Rosie, Anumonwo, Charles K., Meisler, Miriam H., Noebels, Jeffrey L., Isom, Lori L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093838/
https://www.ncbi.nlm.nih.gov/pubmed/30128323
http://dx.doi.org/10.1002/acn3.599

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093838/
https://www.ncbi.nlm.nih.gov/pubmed/30128323
http://dx.doi.org/10.1002/acn3.599

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