Cargando…

Alzheimer's genetic risk is reduced in primary age‐related tauopathy: a potential model of resistance?

OBJECTIVE: Nearly all adults >50 years of age have evidence for neurofibrillary tau tangles (NFTs) and a significant proportion of individuals additionally develop amyloid plaques (Aβ) consistent with Alzheimer's disease (AD). In an effort to identify the independent genetic risk factors for...

Descripción completa

Detalles Bibliográficos
Autores principales:	McMillan, Corey T., Lee, Edward B., Jefferson‐George, Kyra, Naj, Adam, Van Deerlin, Vivianna M., Trojanowski, John Q., Wolk, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093846/ https://www.ncbi.nlm.nih.gov/pubmed/30128317 http://dx.doi.org/10.1002/acn3.581

Ejemplares similares

SHORT TELOMERES ASSOCIATE WITH HYPERPHOSPHORYLATED TAU BURDEN IN PRIMARY AGE-RELATED TAUOPATHY
por: McMillan, Corey, et al.
Publicado: (2022)

Tau-focused therapy and tau transmission: Implications for Alzheimer’s Disease and related tauopathies
por: Trojanowski, John Q
Publicado: (2013)

Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study
por: Iida, Megan A., et al.
Publicado: (2021)

Frontotemporal lobar degeneration proteinopathies have disparate microscopic patterns of white and grey matter pathology
por: Giannini, Lucia A. A., et al.
Publicado: (2021)

Signature laminar distributions of pathology in frontotemporal lobar degeneration
por: Ohm, Daniel T., et al.
Publicado: (2022)

Pathological combinations in neurodegenerative disease are heterogeneous and disease-associated
por: Robinson, John L, et al.
Publicado: (2023)

DNA Methylation in Genetic and Sporadic Forms of Neurodegeneration: Lessons from Alzheimer’s, Related Tauopathies and Genetic Tauopathies
por: Zimmer-Bensch, Geraldine, et al.
Publicado: (2021)

Longitudinal structural gray matter and white matter MRI changes in presymptomatic progranulin mutation carriers
por: Olm, Christopher A., et al.
Publicado: (2018)

Genetic prediction of impulse control disorders in Parkinson's disease
por: Weintraub, Daniel, et al.
Publicado: (2022)

Brain-Penetrant, Orally Bioavailable Microtubule-Stabilizing Small Molecules Are Potential Candidate Therapeutics for Alzheimer’s Disease and Related Tauopathies
por: Lou, Kevin, et al.
Publicado: (2014)

TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss
por: Feng, Tuancheng, et al.
Publicado: (2022)

Tau deposition patterns are associated with functional connectivity in primary tauopathies
por: Franzmeier, Nicolai, et al.
Publicado: (2022)

Clinical diagnoses among individuals with primary age-related tauopathy versus Alzheimer’s neuropathology
por: Teylan, Merilee, et al.
Publicado: (2019)

Transcriptional Signatures of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer’s Disease
por: Stein-O’Brien, Genevieve L, et al.
Publicado: (2023)

Untangling the Tauopathy for Alzheimer’s disease and parkinsonism
por: Chang, Hui-Yun, et al.
Publicado: (2018)

Microglial Activation Correlates with Disease Progression and Upper Motor Neuron Clinical Symptoms in Amyotrophic Lateral Sclerosis
por: Brettschneider, Johannes, et al.
Publicado: (2012)

Pathological drivers of neurodegeneration in suspected non-Alzheimer’s disease pathophysiology
por: Wisse, L. E. M., et al.
Publicado: (2021)

Primary Feline Tauopathy: Clinical, Morphological, Immunohistochemical, and Genetic Studies
por: Vidal-Palencia, Laura, et al.
Publicado: (2023)

Phosphorylated Tau in Alzheimer’s Disease and Other Tauopathies
por: Rawat, Priyanka, et al.
Publicado: (2022)

Transmission of tauopathy strains is independent of their isoform composition
por: He, Zhuohao, et al.
Publicado: (2020)

Empiric Methods to Account for Pre-analytical Variability in Digital Histopathology in Frontotemporal Lobar Degeneration
por: Giannini, Lucia A. A., et al.
Publicado: (2019)

TDP‐43 and tau concurrence in the entorhinal subfields in primary age‐related tauopathy and preclinical Alzheimer's disease
por: Llamas‐Rodríguez, Josué, et al.
Publicado: (2023)

Genetic and Transcriptomic Profiles of Inflammation in Neurodegenerative Diseases: Alzheimer, Parkinson, Creutzfeldt-Jakob and Tauopathies
por: López González, Irene, et al.
Publicado: (2016)

Common neuropathological features underlie distinct clinical presentations in three siblings with hereditary diffuse leukoencephalopathy with spheroids caused by CSF1R p.Arg782His
por: Robinson, John L., et al.
Publicado: (2015)

Primary Age-Related Tauopathy in Human Subcortical Nuclei
por: Zhu, Keqing, et al.
Publicado: (2019)

Influence of APOE genotype in primary age-related tauopathy
por: Robinson, Andrew C., et al.
Publicado: (2020)

Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain
por: Busch, Johanna I, et al.
Publicado: (2013)

PET Imaging of Tau Pathology in Alzheimer’s Disease and Tauopathies
por: James, Olga G., et al.
Publicado: (2015)

Prospects for strain-specific immunotherapy in Alzheimer’s disease and tauopathies
por: Bittar, Alice, et al.
Publicado: (2018)

Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?
por: Laurent, Cyril, et al.
Publicado: (2018)

Effects of Deferasirox in Alzheimer’s Disease and Tauopathy Animal Models
por: Kwan, Ping, et al.
Publicado: (2022)

Type-I Interferons in Alzheimer's Disease and Other Tauopathies
por: Sanford, Sophie A. I., et al.
Publicado: (2022)

Cellular and pathological heterogeneity of primary tauopathies
por: Chung, Dah-eun Chloe, et al.
Publicado: (2021)

Specific post-translational modifications of soluble tau protein distinguishes Alzheimer’s disease and primary tauopathies
por: Kyalu Ngoie Zola, Nathalie, et al.
Publicado: (2023)

Divergent Histopathological Networks of Frontotemporal Degeneration Proteinopathy Subytpes
por: Chen, Min, et al.
Publicado: (2022)

The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer’s disease
por: Stutzbach, Lauren D, et al.
Publicado: (2013)

A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model
por: Zhang, Bin, et al.
Publicado: (2018)

Decision-Making Deficits Associated with Amyloidosis in Lewy Body Disorders
por: Spotorno, Nicola, et al.
Publicado: (2017)

Tau immunotherapy is associated with glial responses in FTLD-tau
por: Kim, Boram, et al.
Publicado: (2021)

Deep learning‐based model for diagnosing Alzheimer's disease and tauopathies
por: Koga, Shunsuke, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_d7cqtbggbcklbmsnu8if2sk5oc