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7 Tesla MRI of Balo's concentric sclerosis versus multiple sclerosis lesions
BACKGROUND: Baló's concentric sclerosis (BCS) is a rare condition characterized by concentrically layered white matter lesions. While its pathogenesis is unknown, hypoxia‐induced tissue injury and chemotactic stimuli have been proposed as potential causes of BCS lesion formation. BCS has been s...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093849/ https://www.ncbi.nlm.nih.gov/pubmed/30128315 http://dx.doi.org/10.1002/acn3.572 |
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author | Behrens, Janina R. Wanner, Julia Kuchling, Joseph Ostendorf, Lennard Harms, Lutz Ruprecht, Klemens Niendorf, Thoralf Jarius, Sven Wildemann, Brigitte Gieß, René M. Scheel, Michael Bellmann‐Strobl, Judith Wuerfel, Jens Paul, Friedemann Sinnecker, Tim |
author_facet | Behrens, Janina R. Wanner, Julia Kuchling, Joseph Ostendorf, Lennard Harms, Lutz Ruprecht, Klemens Niendorf, Thoralf Jarius, Sven Wildemann, Brigitte Gieß, René M. Scheel, Michael Bellmann‐Strobl, Judith Wuerfel, Jens Paul, Friedemann Sinnecker, Tim |
author_sort | Behrens, Janina R. |
collection | PubMed |
description | BACKGROUND: Baló's concentric sclerosis (BCS) is a rare condition characterized by concentrically layered white matter lesions. While its pathogenesis is unknown, hypoxia‐induced tissue injury and chemotactic stimuli have been proposed as potential causes of BCS lesion formation. BCS has been suggested to be a variant of multiple sclerosis (MS). Here, we aimed to elucidate similarities and differences between BCS and MS by describing lesion morphology and localization in high‐resolution 7 Tesla (7 T) magnetic resonance imaging (MRI) scans. METHODS: Ten patients with Baló‐type lesions underwent 7 T MRI, and 10 relapsing remitting MS patients served as controls. The 7 T MR imaging protocol included 3D T(1)‐weighted (T(1)w) magnetization‐prepared rapid gradient echo, 2D high spatial resolution T(2)*‐weighted (T(2)*w) fast low‐angle shot and susceptibility‐weighted imaging. RESULTS: Intralesional veins were visible in the center of all but one Baló‐type lesion. Four Baló‐type lesions displayed inhomogeneous intralesional T(2)*w signal intensities, which are suggestive of microhemorrhages or small ectatic venules. Eight of 10 BCS patients presented with 97 additional lesions, 36 of which (37%) had a central vein. Lesions involving the cortical gray matter and the U‐fibers were not detected in BCS patients. CONCLUSION: Our findings support the hypothesis that BCS and MS share common pathogenetic mechanisms but patients present with different lesion phenotypes. |
format | Online Article Text |
id | pubmed-6093849 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60938492018-08-20 7 Tesla MRI of Balo's concentric sclerosis versus multiple sclerosis lesions Behrens, Janina R. Wanner, Julia Kuchling, Joseph Ostendorf, Lennard Harms, Lutz Ruprecht, Klemens Niendorf, Thoralf Jarius, Sven Wildemann, Brigitte Gieß, René M. Scheel, Michael Bellmann‐Strobl, Judith Wuerfel, Jens Paul, Friedemann Sinnecker, Tim Ann Clin Transl Neurol Research Articles BACKGROUND: Baló's concentric sclerosis (BCS) is a rare condition characterized by concentrically layered white matter lesions. While its pathogenesis is unknown, hypoxia‐induced tissue injury and chemotactic stimuli have been proposed as potential causes of BCS lesion formation. BCS has been suggested to be a variant of multiple sclerosis (MS). Here, we aimed to elucidate similarities and differences between BCS and MS by describing lesion morphology and localization in high‐resolution 7 Tesla (7 T) magnetic resonance imaging (MRI) scans. METHODS: Ten patients with Baló‐type lesions underwent 7 T MRI, and 10 relapsing remitting MS patients served as controls. The 7 T MR imaging protocol included 3D T(1)‐weighted (T(1)w) magnetization‐prepared rapid gradient echo, 2D high spatial resolution T(2)*‐weighted (T(2)*w) fast low‐angle shot and susceptibility‐weighted imaging. RESULTS: Intralesional veins were visible in the center of all but one Baló‐type lesion. Four Baló‐type lesions displayed inhomogeneous intralesional T(2)*w signal intensities, which are suggestive of microhemorrhages or small ectatic venules. Eight of 10 BCS patients presented with 97 additional lesions, 36 of which (37%) had a central vein. Lesions involving the cortical gray matter and the U‐fibers were not detected in BCS patients. CONCLUSION: Our findings support the hypothesis that BCS and MS share common pathogenetic mechanisms but patients present with different lesion phenotypes. John Wiley and Sons Inc. 2018-06-29 /pmc/articles/PMC6093849/ /pubmed/30128315 http://dx.doi.org/10.1002/acn3.572 Text en © 2018 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Behrens, Janina R. Wanner, Julia Kuchling, Joseph Ostendorf, Lennard Harms, Lutz Ruprecht, Klemens Niendorf, Thoralf Jarius, Sven Wildemann, Brigitte Gieß, René M. Scheel, Michael Bellmann‐Strobl, Judith Wuerfel, Jens Paul, Friedemann Sinnecker, Tim 7 Tesla MRI of Balo's concentric sclerosis versus multiple sclerosis lesions |
title | 7 Tesla MRI of Balo's concentric sclerosis versus multiple sclerosis lesions |
title_full | 7 Tesla MRI of Balo's concentric sclerosis versus multiple sclerosis lesions |
title_fullStr | 7 Tesla MRI of Balo's concentric sclerosis versus multiple sclerosis lesions |
title_full_unstemmed | 7 Tesla MRI of Balo's concentric sclerosis versus multiple sclerosis lesions |
title_short | 7 Tesla MRI of Balo's concentric sclerosis versus multiple sclerosis lesions |
title_sort | 7 tesla mri of balo's concentric sclerosis versus multiple sclerosis lesions |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093849/ https://www.ncbi.nlm.nih.gov/pubmed/30128315 http://dx.doi.org/10.1002/acn3.572 |
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