The first transmembrane region of complement component-9 acts as a brake on its self-assembly

Complement component 9 (C9) functions as the pore-forming component of the Membrane Attack Complex (MAC). During MAC assembly, multiple copies of C9 are sequentially recruited to membrane associated C5b8 to form a pore. Here we determined the 2.2 Å crystal structure of monomeric murine C9 and the 3....

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Detalles Bibliográficos
Autores principales: Spicer, Bradley A., Law, Ruby H. P., Caradoc-Davies, Tom T., Ekkel, Sue M., Bayly-Jones, Charles, Pang, Siew-Siew, Conroy, Paul J., Ramm, Georg, Radjainia, Mazdak, Venugopal, Hariprasad, Whisstock, James C., Dunstone, Michelle A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093860/
https://www.ncbi.nlm.nih.gov/pubmed/30111885
http://dx.doi.org/10.1038/s41467-018-05717-0

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