Practical Three-Minute Synthesis of Acid-Coated Fluorescent Carbon Dots with Tuneable Core Structure

We report a one-pot, three-minute synthesis of carboxylic acid-decorated fluorescent carbon dots (COOH-FCDs) with tuneable core morphology dependent on the surface passivating agent. Mechanism investigations highlighted the presence of key pyrazine and polyhydroxyl aromatic motifs, which are formed...

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Autores principales: Hill, Stephen A., Benito-Alifonso, David, Davis, Sean A., Morgan, David J., Berry, Monica, Galan, M. Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093873/
https://www.ncbi.nlm.nih.gov/pubmed/30111806
http://dx.doi.org/10.1038/s41598-018-29674-2
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author Hill, Stephen A.
Benito-Alifonso, David
Davis, Sean A.
Morgan, David J.
Berry, Monica
Galan, M. Carmen
author_facet Hill, Stephen A.
Benito-Alifonso, David
Davis, Sean A.
Morgan, David J.
Berry, Monica
Galan, M. Carmen
author_sort Hill, Stephen A.
collection PubMed
description We report a one-pot, three-minute synthesis of carboxylic acid-decorated fluorescent carbon dots (COOH-FCDs) with tuneable core morphology dependent on the surface passivating agent. Mechanism investigations highlighted the presence of key pyrazine and polyhydroxyl aromatic motifs, which are formed from the degradation of glucosamine in the presence of a bifunctional linker bearing acid and amine groups. The novel COOH-FCDs are selective Fe(3+) and hemin sensors. Furthermore, the FCDs are shown to be non-toxic, fluorescent bioimaging agents for cancer cells.
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spelling pubmed-60938732018-08-20 Practical Three-Minute Synthesis of Acid-Coated Fluorescent Carbon Dots with Tuneable Core Structure Hill, Stephen A. Benito-Alifonso, David Davis, Sean A. Morgan, David J. Berry, Monica Galan, M. Carmen Sci Rep Article We report a one-pot, three-minute synthesis of carboxylic acid-decorated fluorescent carbon dots (COOH-FCDs) with tuneable core morphology dependent on the surface passivating agent. Mechanism investigations highlighted the presence of key pyrazine and polyhydroxyl aromatic motifs, which are formed from the degradation of glucosamine in the presence of a bifunctional linker bearing acid and amine groups. The novel COOH-FCDs are selective Fe(3+) and hemin sensors. Furthermore, the FCDs are shown to be non-toxic, fluorescent bioimaging agents for cancer cells. Nature Publishing Group UK 2018-08-15 /pmc/articles/PMC6093873/ /pubmed/30111806 http://dx.doi.org/10.1038/s41598-018-29674-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Hill, Stephen A.
Benito-Alifonso, David
Davis, Sean A.
Morgan, David J.
Berry, Monica
Galan, M. Carmen
Practical Three-Minute Synthesis of Acid-Coated Fluorescent Carbon Dots with Tuneable Core Structure
title Practical Three-Minute Synthesis of Acid-Coated Fluorescent Carbon Dots with Tuneable Core Structure
title_full Practical Three-Minute Synthesis of Acid-Coated Fluorescent Carbon Dots with Tuneable Core Structure
title_fullStr Practical Three-Minute Synthesis of Acid-Coated Fluorescent Carbon Dots with Tuneable Core Structure
title_full_unstemmed Practical Three-Minute Synthesis of Acid-Coated Fluorescent Carbon Dots with Tuneable Core Structure
title_short Practical Three-Minute Synthesis of Acid-Coated Fluorescent Carbon Dots with Tuneable Core Structure
title_sort practical three-minute synthesis of acid-coated fluorescent carbon dots with tuneable core structure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093873/
https://www.ncbi.nlm.nih.gov/pubmed/30111806
http://dx.doi.org/10.1038/s41598-018-29674-2
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