Novel monoclonal antibody L2A5 specifically targeting sialyl-Tn and short glycans terminated by alpha-2–6 sialic acids

Incomplete O-glycosylation is a feature associated with malignancy resulting in the expression of truncated glycans such as the sialyl-Tn (STn) antigen. Despite all the progress in the development of potential anti-cancer antibodies, their application is frequently hindered by low specificities and...

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Detalles Bibliográficos
Autores principales: Loureiro, Liliana R., Sousa, Diana P., Ferreira, Dylan, Chai, Wengang, Lima, Luís, Pereira, Carina, Lopes, Carla B., Correia, Viviana G., Silva, Lisete M., Li, Chunxia, Santos, Lúcio Lara, Ferreira, José Alexandre, Barbas, Ana, Palma, Angelina S., Novo, Carlos, Videira, Paula A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093877/
https://www.ncbi.nlm.nih.gov/pubmed/30111774
http://dx.doi.org/10.1038/s41598-018-30421-w

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