Decoding topologically associating domains with ultra-low resolution Hi-C data by graph structural entropy

Submegabase-size topologically associating domains (TAD) have been observed in high-throughput chromatin interaction data (Hi-C). However, accurate detection of TADs depends on ultra-deep sequencing and sophisticated normalization procedures. Here we propose a fast and normalization-free method to d...

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Detalles Bibliográficos
Autores principales: Li, Angsheng, Yin, Xianchen, Xu, Bingxiang, Wang, Danyang, Han, Jimin, Wei, Yi, Deng, Yun, Xiong, Ying, Zhang, Zhihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093941/
https://www.ncbi.nlm.nih.gov/pubmed/30111883
http://dx.doi.org/10.1038/s41467-018-05691-7

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