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Pathological Implication of Adipocytes in AAA Development and the Rupture

Abdominal aortic aneurysm (AAA) is a vascular disease that involves the gradual dilation of the abdominal aorta followed by its rupture. AAA is closely associated with weakening of the vascular wall due to oxidative stress, chronic inflammation, and degradation of the extracellular matrix. No effect...

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Detalles Bibliográficos
Autores principales: Kugo, Hirona, Tanaka, Hiroki, Moriyama, Tatsuya, Zaima, Nobuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese College of Angiology / The Japanese Society for Vascular Surgery / Japanese Society of Phlebology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094042/
https://www.ncbi.nlm.nih.gov/pubmed/30116407
http://dx.doi.org/10.3400/avd.ra.17-00130
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author Kugo, Hirona
Tanaka, Hiroki
Moriyama, Tatsuya
Zaima, Nobuhiro
author_facet Kugo, Hirona
Tanaka, Hiroki
Moriyama, Tatsuya
Zaima, Nobuhiro
author_sort Kugo, Hirona
collection PubMed
description Abdominal aortic aneurysm (AAA) is a vascular disease that involves the gradual dilation of the abdominal aorta followed by its rupture. AAA is closely associated with weakening of the vascular wall due to oxidative stress, chronic inflammation, and degradation of the extracellular matrix. No effective drug therapy is currently available for preventing aneurysm progression or rupture. Adipocytes in the vascular wall are reportedly closely associated with AAA development and rupture. Fiber degradation in the aneurysm wall is enhanced by increased numbers of adipocytes, and rupture risk may increase as well. Recent studies suggested that appropriate control of adipocytes in the vascular wall may be an important strategy to prevent AAA rupture, and further studies may aid in the establishment of a method for preventing AAA rupture by therapeutic drugs or functional foods. In this review, we summarize adipocyte function and the correlation between AAA and adipocytes.
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spelling pubmed-60940422018-08-16 Pathological Implication of Adipocytes in AAA Development and the Rupture Kugo, Hirona Tanaka, Hiroki Moriyama, Tatsuya Zaima, Nobuhiro Ann Vasc Dis Review Article Abdominal aortic aneurysm (AAA) is a vascular disease that involves the gradual dilation of the abdominal aorta followed by its rupture. AAA is closely associated with weakening of the vascular wall due to oxidative stress, chronic inflammation, and degradation of the extracellular matrix. No effective drug therapy is currently available for preventing aneurysm progression or rupture. Adipocytes in the vascular wall are reportedly closely associated with AAA development and rupture. Fiber degradation in the aneurysm wall is enhanced by increased numbers of adipocytes, and rupture risk may increase as well. Recent studies suggested that appropriate control of adipocytes in the vascular wall may be an important strategy to prevent AAA rupture, and further studies may aid in the establishment of a method for preventing AAA rupture by therapeutic drugs or functional foods. In this review, we summarize adipocyte function and the correlation between AAA and adipocytes. Japanese College of Angiology / The Japanese Society for Vascular Surgery / Japanese Society of Phlebology 2018-06-25 /pmc/articles/PMC6094042/ /pubmed/30116407 http://dx.doi.org/10.3400/avd.ra.17-00130 Text en Copyright © 2018 Annals of Vascular Diseases http://creativecommons.org/licenses/by-nc-sa/4.0/ ©2018 The Editorial Committee of Annals of Vascular Diseases. This article is distributed under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided the credit of the original work, a link to the license, and indication of any change are properly given, and the original work is not used for commercial purposes. Remixed or transformed contributions must be distributed under the same license as the original.
spellingShingle Review Article
Kugo, Hirona
Tanaka, Hiroki
Moriyama, Tatsuya
Zaima, Nobuhiro
Pathological Implication of Adipocytes in AAA Development and the Rupture
title Pathological Implication of Adipocytes in AAA Development and the Rupture
title_full Pathological Implication of Adipocytes in AAA Development and the Rupture
title_fullStr Pathological Implication of Adipocytes in AAA Development and the Rupture
title_full_unstemmed Pathological Implication of Adipocytes in AAA Development and the Rupture
title_short Pathological Implication of Adipocytes in AAA Development and the Rupture
title_sort pathological implication of adipocytes in aaa development and the rupture
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094042/
https://www.ncbi.nlm.nih.gov/pubmed/30116407
http://dx.doi.org/10.3400/avd.ra.17-00130
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