What’s in a (Sub)strain?

C57BL/6J and C57BL/6N inbred mice are widely, and often interchangeably, used for stem cell research; yet, these substrains harbor discrete genetic differences that can cause phenotypic disparities. In this issue of Stem Cell Reports, Morales-Hernández et al. identify one particular difference—disru...

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Detalles Bibliográficos
Autores principales: Goldstein, Jill M., Wagers, Amy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094162/
https://www.ncbi.nlm.nih.gov/pubmed/30110622
http://dx.doi.org/10.1016/j.stemcr.2018.07.011
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author Goldstein, Jill M.
Wagers, Amy J.
author_facet Goldstein, Jill M.
Wagers, Amy J.
author_sort Goldstein, Jill M.
collection PubMed
description C57BL/6J and C57BL/6N inbred mice are widely, and often interchangeably, used for stem cell research; yet, these substrains harbor discrete genetic differences that can cause phenotypic disparities. In this issue of Stem Cell Reports, Morales-Hernández et al. identify one particular difference—disruption of Nicotinamide Nucleotide Transhydrogenase (Nnt)—that increases reactive oxygen exposure and impairs hematopoietic progenitor cell function in C57BL/6J, as compared to C57BL/6N, mice.
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spelling pubmed-60941622018-08-16 What’s in a (Sub)strain? Goldstein, Jill M. Wagers, Amy J. Stem Cell Reports Preview C57BL/6J and C57BL/6N inbred mice are widely, and often interchangeably, used for stem cell research; yet, these substrains harbor discrete genetic differences that can cause phenotypic disparities. In this issue of Stem Cell Reports, Morales-Hernández et al. identify one particular difference—disruption of Nicotinamide Nucleotide Transhydrogenase (Nnt)—that increases reactive oxygen exposure and impairs hematopoietic progenitor cell function in C57BL/6J, as compared to C57BL/6N, mice. Elsevier 2018-08-14 /pmc/articles/PMC6094162/ /pubmed/30110622 http://dx.doi.org/10.1016/j.stemcr.2018.07.011 Text en © 2018 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Preview
Goldstein, Jill M.
Wagers, Amy J.
What’s in a (Sub)strain?
title What’s in a (Sub)strain?
title_full What’s in a (Sub)strain?
title_fullStr What’s in a (Sub)strain?
title_full_unstemmed What’s in a (Sub)strain?
title_short What’s in a (Sub)strain?
title_sort what’s in a (sub)strain?
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094162/
https://www.ncbi.nlm.nih.gov/pubmed/30110622
http://dx.doi.org/10.1016/j.stemcr.2018.07.011
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