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Investigating allosteric effects on the functional dynamics of β2-adrenergic ternary complexes with enhanced-sampling simulations

Signalling by G-protein coupled receptors usually occurs via ternary complexes formed under cooperative binding between the receptor, a ligand and an intracellular binding partner (a G-protein or β-arrestin). While a global rational for allosteric effects in ternary complexes would be of great help...

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Detalles Bibliográficos
Autores principales:	Saleh, Noureldin, Saladino, Giorgio, Gervasio, Francesco Luigi, Clark, Timothy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2017
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094175/ https://www.ncbi.nlm.nih.gov/pubmed/30155211 http://dx.doi.org/10.1039/c6sc04647a

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