Specific Inhibition of Hepatic Lactate Dehydrogenase Reduces Oxalate Production in Mouse Models of Primary Hyperoxaluria

Primary hyperoxalurias (PHs) are autosomal recessive disorders caused by the overproduction of oxalate leading to calcium oxalate precipitation in the kidney and eventually to end-stage renal disease. One promising strategy to treat PHs is to reduce the hepatic production of oxalate through substrat...

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Detalles Bibliográficos
Autores principales: Lai, Chengjung, Pursell, Natalie, Gierut, Jessica, Saxena, Utsav, Zhou, Wei, Dills, Michael, Diwanji, Rohan, Dutta, Chaitali, Koser, Martin, Nazef, Naim, Storr, Rachel, Kim, Boyoung, Martin-Higueras, Cristina, Salido, Eduardo, Wang, Weimin, Abrams, Marc, Dudek, Henryk, Brown, Bob D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094358/
https://www.ncbi.nlm.nih.gov/pubmed/29914758
http://dx.doi.org/10.1016/j.ymthe.2018.05.016

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