Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity

Regulatory T cells (Tregs) are critical for maintaining immune homeostasis, but their presence in tumor tissues impairs anti-tumor immunity and portends poor prognoses in cancer patients. Here, we reveal a mechanism to selectively target and reprogram the function of tumor-infiltrating Tregs (TI-Tre...

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Detalles Bibliográficos
Autores principales: Wang, David, Quiros, Jason, Mahuron, Kelly, Pai, Chien-Chun, Ranzani, Valeria, Young, Arabella, Silveria, Stephanie, Harwin, Tory, Abnousian, Arbi, Pagani, Massimiliano, Rosenblum, Michael D., Van Gool, Frederic, Fong, Lawrence, Bluestone, Jeffrey A., DuPage, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094952/
https://www.ncbi.nlm.nih.gov/pubmed/29898397
http://dx.doi.org/10.1016/j.celrep.2018.05.050

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