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Socioeconomic Status Is Associated With Antibody Levels Against Vaccine Preventable Diseases in the Netherlands

Background: We investigated whether low socioeconomic status (SES), which is associated with reduced health and life expectancy, might play a role in increased risk for infectious diseases. Therefore, we explored the association between SES and immunoglobulin G (IgG) levels against various pathogens...

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Autores principales: Hoes, Joske, Boef, Anna G. C., Knol, Mirjam J., de Melker, Hester E., Mollema, Liesbeth, van der Klis, Fiona R. M., Rots, Nynke Y., van Baarle, Debbie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094970/
https://www.ncbi.nlm.nih.gov/pubmed/30140666
http://dx.doi.org/10.3389/fpubh.2018.00209
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author Hoes, Joske
Boef, Anna G. C.
Knol, Mirjam J.
de Melker, Hester E.
Mollema, Liesbeth
van der Klis, Fiona R. M.
Rots, Nynke Y.
van Baarle, Debbie
author_facet Hoes, Joske
Boef, Anna G. C.
Knol, Mirjam J.
de Melker, Hester E.
Mollema, Liesbeth
van der Klis, Fiona R. M.
Rots, Nynke Y.
van Baarle, Debbie
author_sort Hoes, Joske
collection PubMed
description Background: We investigated whether low socioeconomic status (SES), which is associated with reduced health and life expectancy, might play a role in increased risk for infectious diseases. Therefore, we explored the association between SES and immunoglobulin G (IgG) levels against various pathogens. Methods: We analyzed the association between SES [educational level and net household income (NHI)] and serum IgG concentration against measles, mumps, rubella, varicella, Haemophilus influenzae type B (HiB), pneumococcus, meningococcus serogroup C (MenC), and cytomegalovirus (CMV) collected within a national cross-sectional serosurvey (2006/2007) using linear regression analyses among non-vaccinated individuals. Results: Higher educational level was associated with higher IgG concentrations against measles (GMC ratio 1.34, 95% CI 1.18–1.53) and rubella (1.13, 1.02–1.25) compared to low education level. In contrast, higher education level was associated with lower IgG concentrations against pneumococcus (0.78, 0.70–0.88), MenC (0.54, 0.44–0.68), and CMV (0.23, 0.18–0.31) compared to low education level. This pattern was also evident when NHI was used as SES indicator. Conclusion: Our study suggests that socioeconomic status is associated with antibody levels in a pathogen-dependent manner. The results suggest that differences in serological response upon infection or differences in exposure might be involved in the variation in IgG levels between SES groups.
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spelling pubmed-60949702018-08-23 Socioeconomic Status Is Associated With Antibody Levels Against Vaccine Preventable Diseases in the Netherlands Hoes, Joske Boef, Anna G. C. Knol, Mirjam J. de Melker, Hester E. Mollema, Liesbeth van der Klis, Fiona R. M. Rots, Nynke Y. van Baarle, Debbie Front Public Health Public Health Background: We investigated whether low socioeconomic status (SES), which is associated with reduced health and life expectancy, might play a role in increased risk for infectious diseases. Therefore, we explored the association between SES and immunoglobulin G (IgG) levels against various pathogens. Methods: We analyzed the association between SES [educational level and net household income (NHI)] and serum IgG concentration against measles, mumps, rubella, varicella, Haemophilus influenzae type B (HiB), pneumococcus, meningococcus serogroup C (MenC), and cytomegalovirus (CMV) collected within a national cross-sectional serosurvey (2006/2007) using linear regression analyses among non-vaccinated individuals. Results: Higher educational level was associated with higher IgG concentrations against measles (GMC ratio 1.34, 95% CI 1.18–1.53) and rubella (1.13, 1.02–1.25) compared to low education level. In contrast, higher education level was associated with lower IgG concentrations against pneumococcus (0.78, 0.70–0.88), MenC (0.54, 0.44–0.68), and CMV (0.23, 0.18–0.31) compared to low education level. This pattern was also evident when NHI was used as SES indicator. Conclusion: Our study suggests that socioeconomic status is associated with antibody levels in a pathogen-dependent manner. The results suggest that differences in serological response upon infection or differences in exposure might be involved in the variation in IgG levels between SES groups. Frontiers Media S.A. 2018-07-27 /pmc/articles/PMC6094970/ /pubmed/30140666 http://dx.doi.org/10.3389/fpubh.2018.00209 Text en Copyright © Hoes, Boef, Knol, de Melker, Mollema, van der Klis, Rots and van Baarle. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Hoes, Joske
Boef, Anna G. C.
Knol, Mirjam J.
de Melker, Hester E.
Mollema, Liesbeth
van der Klis, Fiona R. M.
Rots, Nynke Y.
van Baarle, Debbie
Socioeconomic Status Is Associated With Antibody Levels Against Vaccine Preventable Diseases in the Netherlands
title Socioeconomic Status Is Associated With Antibody Levels Against Vaccine Preventable Diseases in the Netherlands
title_full Socioeconomic Status Is Associated With Antibody Levels Against Vaccine Preventable Diseases in the Netherlands
title_fullStr Socioeconomic Status Is Associated With Antibody Levels Against Vaccine Preventable Diseases in the Netherlands
title_full_unstemmed Socioeconomic Status Is Associated With Antibody Levels Against Vaccine Preventable Diseases in the Netherlands
title_short Socioeconomic Status Is Associated With Antibody Levels Against Vaccine Preventable Diseases in the Netherlands
title_sort socioeconomic status is associated with antibody levels against vaccine preventable diseases in the netherlands
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094970/
https://www.ncbi.nlm.nih.gov/pubmed/30140666
http://dx.doi.org/10.3389/fpubh.2018.00209
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