Cargando…

CAR T Cells in Solid Tumors: Blueprints for Building Effective Therapies

Genetic redirection of T lymphocytes with chimeric antigen receptors (CARs) has soared from treating cancers preclinically to FDA approval for hematologic malignancies and commercial-grade production scale in under 30 years. To date, solid tumors are less susceptible to CAR therapies and instead hav...

Descripción completa

Detalles Bibliográficos
Autores principales:	Knochelmann, Hannah M., Smith, Aubrey S., Dwyer, Connor J., Wyatt, Megan M., Mehrotra, Shikhar, Paulos, Chrystal M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094980/ https://www.ncbi.nlm.nih.gov/pubmed/30140266 http://dx.doi.org/10.3389/fimmu.2018.01740

Ejemplares similares

Fundamentals of T Cell Metabolism and Strategies to Enhance Cancer Immunotherapy
por: Rangel Rivera, Guillermo O., et al.
Publicado: (2021)

Fueling Cancer Immunotherapy With Common Gamma Chain Cytokines
por: Dwyer, Connor J., et al.
Publicado: (2019)

Ex vivo blockade of PI3K gamma or delta signaling enhances the antitumor potency of adoptively transferred CD8(+) T cells
por: Dwyer, Connor J., et al.
Publicado: (2020)

Modeling ex vivo tumor-infiltrating lymphocyte expansion from established solid malignancies
por: Knochelmann, Hannah M, et al.
Publicado: (2021)

Th17 Cells in Cancer: The Ultimate Identity Crisis
por: Bailey, Stefanie R., et al.
Publicado: (2014)

B cells imprint adoptively transferred CD8(+) T cells with enhanced tumor immunity
por: Smith, Aubrey S, et al.
Publicado: (2022)

PI3Kδ Inhibition Enhances the Antitumor Fitness of Adoptively Transferred CD8(+) T Cells
por: Bowers, Jacob S., et al.
Publicado: (2017)

Clinical Investigations of CAR-T Cell Therapy for Solid Tumors
por: Chen, Kun, et al.
Publicado: (2022)

Making CAR T Cells a Solid Option for Solid Tumors
por: Schmidts, Andrea, et al.
Publicado: (2018)

Combining chemotherapy with CAR-T cell therapy in treating solid tumors
por: Wang, Arthur Xuan, et al.
Publicado: (2023)

Expanding the Therapeutic Window for CAR T Cell Therapy in Solid Tumors: The Knowns and Unknowns of CAR T Cell Biology
por: Watanabe, Keisuke, et al.
Publicado: (2018)

Bright future or blind alley? CAR-T cell therapy for solid tumors
por: Zhang, Kai, et al.
Publicado: (2023)

Identification of human CD4(+) T cell populations with distinct antitumor activity
por: Nelson, Michelle H., et al.
Publicado: (2020)

Engineered CAR-Macrophages as Adoptive Immunotherapies for Solid Tumors
por: Sloas, Christopher, et al.
Publicado: (2021)

Advances in Nanotechnology Development to Overcome Current Roadblocks in CAR-T Therapy for Solid Tumors
por: Mi, Juan, et al.
Publicado: (2022)

Enhancing CAR T-cell therapies against solid tumors: Mechanisms and reversion of resistance
por: Qin, Yue, et al.
Publicado: (2022)

Engineering CAR-T Cells for Improved Function Against Solid Tumors
por: Morgan, Michael A., et al.
Publicado: (2018)

Obstacles and Coping Strategies of CAR-T Cell Immunotherapy in Solid Tumors
por: Miao, Lele, et al.
Publicado: (2021)

Revolution of CAR Engineering For Next-Generation Immunotherapy In Solid Tumors
por: Yu, Tao, et al.
Publicado: (2022)

Genetic Modification of Cytokine Signaling to Enhance Efficacy of CAR T Cell Therapy in Solid Tumors
por: Ghahri-Saremi, Navid, et al.
Publicado: (2021)

Recent Advances in Solid Tumor CAR-T Cell Therapy: Driving Tumor Cells From Hero to Zero?
por: Safarzadeh Kozani, Pouya, et al.
Publicado: (2022)

CAR T Cells for Solid Tumors: New Strategies for Finding, Infiltrating, and Surviving in the Tumor Microenvironment
por: Martinez, Marina, et al.
Publicado: (2019)

PD-1(Hi) CAR-T cells provide superior protection against solid tumors
por: Sailer, Cooper J., et al.
Publicado: (2023)

The In Vivo Transcriptomic Blueprint of Mycobacterium tuberculosis in the Lung
por: Coppola, Mariateresa, et al.
Publicado: (2021)

The current landscape of CAR T-cell therapy for solid tumors: Mechanisms, research progress, challenges, and counterstrategies
por: Daei Sorkhabi, Amin, et al.
Publicado: (2023)

CAR-T Cells and Oncolytic Viruses: Joining Forces to Overcome the Solid Tumor Challenge
por: Guedan, Sonia, et al.
Publicado: (2018)

Genetic Modification Strategies to Enhance CAR T Cell Persistence for Patients With Solid Tumors
por: DeRenzo, Christopher, et al.
Publicado: (2019)

CAR Talk: How Cancer-Specific CAR T Cells Can Instruct How to Build CAR T Cells to Cure HIV
por: Kim, Gloria B., et al.
Publicado: (2019)

Advances in CAR-T Cell Genetic Engineering Strategies to Overcome Hurdles in Solid Tumors Treatment
por: Andrea, Alain E., et al.
Publicado: (2022)

Self-delivery of TIGIT-blocking scFv enhances CAR-T immunotherapy in solid tumors
por: Yang, Fan, et al.
Publicado: (2023)

Building blocks and blueprints for bacterial autolysins
por: Mitchell, Spencer J., et al.
Publicado: (2021)

CAR-T Therapies in Solid Tumors: Opportunities and Challenges
por: Guzman, Grace, et al.
Publicado: (2023)

Chimeric Antigen Receptor (CAR) Regulatory T-Cells in Solid Organ Transplantation
por: Gille, Ilse, et al.
Publicado: (2022)

Update for Advance CAR-T Therapy in Solid Tumors, Clinical Application in Peritoneal Carcinomatosis From Colorectal Cancer and Future Prospects
por: Qian, Siyuan, et al.
Publicado: (2022)

Immunological effects of nivolumab immunotherapy in patients with oral cavity squamous cell carcinoma
por: Xiong, Ying, et al.
Publicado: (2020)

An IL-4/21 Inverted Cytokine Receptor Improving CAR-T Cell Potency in Immunosuppressive Solid-Tumor Microenvironment
por: Wang, Yi, et al.
Publicado: (2019)

Befriending the Hostile Tumor Microenvironment in CAR T-Cell Therapy
por: Lindo, Lorenzo, et al.
Publicado: (2021)

Strategies to Overcome Failures in T-Cell Immunotherapies by Targeting PI3K-δ and –γ
por: Chandrasekaran, Sanjay, et al.
Publicado: (2021)

Blueprints visual scripting for unreal engine: the faster way to build games using UE4 blueprints
por: Romero, Marcos, et al.
Publicado: (2019)

Persistent Inflammation and Nitric Oxide Dysregulation Are Transcriptomic Blueprints of Subglottic Stenosis
por: Nguyen, Hoang C. B., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_blsa9jsk5f52bqvhvvgij9sd9c