Oral methylnaltrexone does not negatively impact analgesia in patients with opioid-induced constipation and chronic noncancer pain

PURPOSE: An oral formulation of methylnaltrexone has been developed for treating opioid-induced constipation (OIC). This manuscript examines the impact of oral methylnaltrexone, a peripherally acting µ-opioid receptor antagonist, on opioid analgesia. METHODS: This Phase III, randomized, double-blind...

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Detalles Bibliográficos
Autores principales: Webster, Lynn R, Israel, Robert J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095122/
https://www.ncbi.nlm.nih.gov/pubmed/30147355
http://dx.doi.org/10.2147/JPR.S160488

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095122/
https://www.ncbi.nlm.nih.gov/pubmed/30147355
http://dx.doi.org/10.2147/JPR.S160488

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