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Oral methylnaltrexone does not negatively impact analgesia in patients with opioid-induced constipation and chronic noncancer pain

PURPOSE: An oral formulation of methylnaltrexone has been developed for treating opioid-induced constipation (OIC). This manuscript examines the impact of oral methylnaltrexone, a peripherally acting µ-opioid receptor antagonist, on opioid analgesia. METHODS: This Phase III, randomized, double-blind...

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Detalles Bibliográficos
Autores principales:	Webster, Lynn R, Israel, Robert J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095122/ https://www.ncbi.nlm.nih.gov/pubmed/30147355 http://dx.doi.org/10.2147/JPR.S160488

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