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Detection of aberrant crypt foci with image-enhanced endoscopy

Background and study aims  Conventional detection of aberrant crypt foci (ACF) with dye-spraying and magnifying observation is labor- and skill-intensive. We performed a prospective non-inferiority study to investigate the utility of image-enhanced endoscopy (IEE) for detection of ACF. Patients and...

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Autores principales: Kagemoto, Kaizo, Okamoto, Koichi, Takaoka, Toshi, Sato, Yasushi, Kitamura, Shinji, Kimura, Tetsuo, Sogabe, Masahiro, Miyamoto, Hiroshi, Muguruma, Naoki, Tsuneyama, Koichi, Takayama, Tetsuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: © Georg Thieme Verlag KG 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095220/
https://www.ncbi.nlm.nih.gov/pubmed/30123821
http://dx.doi.org/10.1055/a-0621-8794
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author Kagemoto, Kaizo
Okamoto, Koichi
Takaoka, Toshi
Sato, Yasushi
Kitamura, Shinji
Kimura, Tetsuo
Sogabe, Masahiro
Miyamoto, Hiroshi
Muguruma, Naoki
Tsuneyama, Koichi
Takayama, Tetsuji
author_facet Kagemoto, Kaizo
Okamoto, Koichi
Takaoka, Toshi
Sato, Yasushi
Kitamura, Shinji
Kimura, Tetsuo
Sogabe, Masahiro
Miyamoto, Hiroshi
Muguruma, Naoki
Tsuneyama, Koichi
Takayama, Tetsuji
author_sort Kagemoto, Kaizo
collection PubMed
description Background and study aims  Conventional detection of aberrant crypt foci (ACF) with dye-spraying and magnifying observation is labor- and skill-intensive. We performed a prospective non-inferiority study to investigate the utility of image-enhanced endoscopy (IEE) for detection of ACF. Patients and methods  Patients with a history of colorectal neoplasm were eligible. The number of ACF in the lower rectum was counted first using IEE magnification with narrow-band imaging (NBI) or blue-laser imaging (BLI), and subsequently using the methylene blue method. The primary endpoint was the ACF detection rate with IEE, i. e., the number of ACF detected with IEE relative to the number of ACF detected with methylene blue. The secondary endpoints were bowel preparation time, ACF detection time, and the detection rate with NBI or BLI. Results  A total of 40 patients were enrolled (NBI 20 and BLI 20). The overall detection rate for ACF with IEE was 81.7 % (503/616; 95 %CI 78.8 – 84.6 %), meeting the primary endpoint. The detection rate for ACF with BLI (84.9 %, 258/304) was significantly higher than with NBI (78.5 %, 245/312; P  < 0.05). Both bowel preparation time and ACF detection time were significantly shorter with IEE versus the methylene blue method ( P  < 0.01, respectively). The detection rates for dysplastic and non-dysplastic ACF with IEE were 84.4 % (27/32) and 80.3 % (469/584), respectively. Conclusion  IEE is able to detect ACF during colonoscopy with sensitivity non-inferior to that of the conventional methylene blue method. IEE is simpler than the methylene blue method and is therefore a potentially useful new tool for ACF detection.
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spelling pubmed-60952202018-08-17 Detection of aberrant crypt foci with image-enhanced endoscopy Kagemoto, Kaizo Okamoto, Koichi Takaoka, Toshi Sato, Yasushi Kitamura, Shinji Kimura, Tetsuo Sogabe, Masahiro Miyamoto, Hiroshi Muguruma, Naoki Tsuneyama, Koichi Takayama, Tetsuji Endosc Int Open Background and study aims  Conventional detection of aberrant crypt foci (ACF) with dye-spraying and magnifying observation is labor- and skill-intensive. We performed a prospective non-inferiority study to investigate the utility of image-enhanced endoscopy (IEE) for detection of ACF. Patients and methods  Patients with a history of colorectal neoplasm were eligible. The number of ACF in the lower rectum was counted first using IEE magnification with narrow-band imaging (NBI) or blue-laser imaging (BLI), and subsequently using the methylene blue method. The primary endpoint was the ACF detection rate with IEE, i. e., the number of ACF detected with IEE relative to the number of ACF detected with methylene blue. The secondary endpoints were bowel preparation time, ACF detection time, and the detection rate with NBI or BLI. Results  A total of 40 patients were enrolled (NBI 20 and BLI 20). The overall detection rate for ACF with IEE was 81.7 % (503/616; 95 %CI 78.8 – 84.6 %), meeting the primary endpoint. The detection rate for ACF with BLI (84.9 %, 258/304) was significantly higher than with NBI (78.5 %, 245/312; P  < 0.05). Both bowel preparation time and ACF detection time were significantly shorter with IEE versus the methylene blue method ( P  < 0.01, respectively). The detection rates for dysplastic and non-dysplastic ACF with IEE were 84.4 % (27/32) and 80.3 % (469/584), respectively. Conclusion  IEE is able to detect ACF during colonoscopy with sensitivity non-inferior to that of the conventional methylene blue method. IEE is simpler than the methylene blue method and is therefore a potentially useful new tool for ACF detection. © Georg Thieme Verlag KG 2018-08 2018-08-01 /pmc/articles/PMC6095220/ /pubmed/30123821 http://dx.doi.org/10.1055/a-0621-8794 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Kagemoto, Kaizo
Okamoto, Koichi
Takaoka, Toshi
Sato, Yasushi
Kitamura, Shinji
Kimura, Tetsuo
Sogabe, Masahiro
Miyamoto, Hiroshi
Muguruma, Naoki
Tsuneyama, Koichi
Takayama, Tetsuji
Detection of aberrant crypt foci with image-enhanced endoscopy
title Detection of aberrant crypt foci with image-enhanced endoscopy
title_full Detection of aberrant crypt foci with image-enhanced endoscopy
title_fullStr Detection of aberrant crypt foci with image-enhanced endoscopy
title_full_unstemmed Detection of aberrant crypt foci with image-enhanced endoscopy
title_short Detection of aberrant crypt foci with image-enhanced endoscopy
title_sort detection of aberrant crypt foci with image-enhanced endoscopy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095220/
https://www.ncbi.nlm.nih.gov/pubmed/30123821
http://dx.doi.org/10.1055/a-0621-8794
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