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Neoadjuvant treatment of biliary tract cancer: state-of-the-art and new perspectives
Gall bladder cancer (GBC), and intrahepatic and extrahepatic (perihilar or distal bile duct's) cholangiocarcinomas (CCA) are usually diagnosed in locally advanced or node-positive stage, with a short survival rate. Thus, it appears essential to explore novel strategies for improving disease dow...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Future Medicine Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095316/ https://www.ncbi.nlm.nih.gov/pubmed/30191029 http://dx.doi.org/10.2217/hep.15.43 |
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author | Imperatori, Marco D'Onofrio, Loretta Marrucci, Eleonora Pantano, Francesco Zoccoli, Alice Tonini, Giuseppe |
author_facet | Imperatori, Marco D'Onofrio, Loretta Marrucci, Eleonora Pantano, Francesco Zoccoli, Alice Tonini, Giuseppe |
author_sort | Imperatori, Marco |
collection | PubMed |
description | Gall bladder cancer (GBC), and intrahepatic and extrahepatic (perihilar or distal bile duct's) cholangiocarcinomas (CCA) are usually diagnosed in locally advanced or node-positive stage, with a short survival rate. Thus, it appears essential to explore novel strategies for improving disease downstage and radical surgery. Chemoradiotherapy followed by liver transplantation seems to be one of the most promising approaches for intrahepatic or perihilar disease while chemotherapy with novel radiotherapy techniques (such stereotactic body radiation) emerged as an attractive preoperative treatment in distal diseases. In this paper, we will review currently available knowledge about neoadjuvant treatment of biliary tract cancers (BTC) paying attention to challenges that make this type of management in clinical practice difficult. |
format | Online Article Text |
id | pubmed-6095316 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Future Medicine Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-60953162018-09-06 Neoadjuvant treatment of biliary tract cancer: state-of-the-art and new perspectives Imperatori, Marco D'Onofrio, Loretta Marrucci, Eleonora Pantano, Francesco Zoccoli, Alice Tonini, Giuseppe Hepat Oncol Review Gall bladder cancer (GBC), and intrahepatic and extrahepatic (perihilar or distal bile duct's) cholangiocarcinomas (CCA) are usually diagnosed in locally advanced or node-positive stage, with a short survival rate. Thus, it appears essential to explore novel strategies for improving disease downstage and radical surgery. Chemoradiotherapy followed by liver transplantation seems to be one of the most promising approaches for intrahepatic or perihilar disease while chemotherapy with novel radiotherapy techniques (such stereotactic body radiation) emerged as an attractive preoperative treatment in distal diseases. In this paper, we will review currently available knowledge about neoadjuvant treatment of biliary tract cancers (BTC) paying attention to challenges that make this type of management in clinical practice difficult. Future Medicine Ltd 2016-01 2015-11-30 /pmc/articles/PMC6095316/ /pubmed/30191029 http://dx.doi.org/10.2217/hep.15.43 Text en © 2016 Giuseppe Tonini This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Review Imperatori, Marco D'Onofrio, Loretta Marrucci, Eleonora Pantano, Francesco Zoccoli, Alice Tonini, Giuseppe Neoadjuvant treatment of biliary tract cancer: state-of-the-art and new perspectives |
title | Neoadjuvant treatment of biliary tract cancer: state-of-the-art and new perspectives |
title_full | Neoadjuvant treatment of biliary tract cancer: state-of-the-art and new perspectives |
title_fullStr | Neoadjuvant treatment of biliary tract cancer: state-of-the-art and new perspectives |
title_full_unstemmed | Neoadjuvant treatment of biliary tract cancer: state-of-the-art and new perspectives |
title_short | Neoadjuvant treatment of biliary tract cancer: state-of-the-art and new perspectives |
title_sort | neoadjuvant treatment of biliary tract cancer: state-of-the-art and new perspectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095316/ https://www.ncbi.nlm.nih.gov/pubmed/30191029 http://dx.doi.org/10.2217/hep.15.43 |
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