Cargando…

Neoadjuvant treatment of biliary tract cancer: state-of-the-art and new perspectives

Gall bladder cancer (GBC), and intrahepatic and extrahepatic (perihilar or distal bile duct's) cholangiocarcinomas (CCA) are usually diagnosed in locally advanced or node-positive stage, with a short survival rate. Thus, it appears essential to explore novel strategies for improving disease dow...

Descripción completa

Detalles Bibliográficos
Autores principales: Imperatori, Marco, D'Onofrio, Loretta, Marrucci, Eleonora, Pantano, Francesco, Zoccoli, Alice, Tonini, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095316/
https://www.ncbi.nlm.nih.gov/pubmed/30191029
http://dx.doi.org/10.2217/hep.15.43
_version_ 1783347936324747264
author Imperatori, Marco
D'Onofrio, Loretta
Marrucci, Eleonora
Pantano, Francesco
Zoccoli, Alice
Tonini, Giuseppe
author_facet Imperatori, Marco
D'Onofrio, Loretta
Marrucci, Eleonora
Pantano, Francesco
Zoccoli, Alice
Tonini, Giuseppe
author_sort Imperatori, Marco
collection PubMed
description Gall bladder cancer (GBC), and intrahepatic and extrahepatic (perihilar or distal bile duct's) cholangiocarcinomas (CCA) are usually diagnosed in locally advanced or node-positive stage, with a short survival rate. Thus, it appears essential to explore novel strategies for improving disease downstage and radical surgery. Chemoradiotherapy followed by liver transplantation seems to be one of the most promising approaches for intrahepatic or perihilar disease while chemotherapy with novel radiotherapy techniques (such stereotactic body radiation) emerged as an attractive preoperative treatment in distal diseases. In this paper, we will review currently available knowledge about neoadjuvant treatment of biliary tract cancers (BTC) paying attention to challenges that make this type of management in clinical practice difficult.
format Online
Article
Text
id pubmed-6095316
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Future Medicine Ltd
record_format MEDLINE/PubMed
spelling pubmed-60953162018-09-06 Neoadjuvant treatment of biliary tract cancer: state-of-the-art and new perspectives Imperatori, Marco D'Onofrio, Loretta Marrucci, Eleonora Pantano, Francesco Zoccoli, Alice Tonini, Giuseppe Hepat Oncol Review Gall bladder cancer (GBC), and intrahepatic and extrahepatic (perihilar or distal bile duct's) cholangiocarcinomas (CCA) are usually diagnosed in locally advanced or node-positive stage, with a short survival rate. Thus, it appears essential to explore novel strategies for improving disease downstage and radical surgery. Chemoradiotherapy followed by liver transplantation seems to be one of the most promising approaches for intrahepatic or perihilar disease while chemotherapy with novel radiotherapy techniques (such stereotactic body radiation) emerged as an attractive preoperative treatment in distal diseases. In this paper, we will review currently available knowledge about neoadjuvant treatment of biliary tract cancers (BTC) paying attention to challenges that make this type of management in clinical practice difficult. Future Medicine Ltd 2016-01 2015-11-30 /pmc/articles/PMC6095316/ /pubmed/30191029 http://dx.doi.org/10.2217/hep.15.43 Text en © 2016 Giuseppe Tonini This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Review
Imperatori, Marco
D'Onofrio, Loretta
Marrucci, Eleonora
Pantano, Francesco
Zoccoli, Alice
Tonini, Giuseppe
Neoadjuvant treatment of biliary tract cancer: state-of-the-art and new perspectives
title Neoadjuvant treatment of biliary tract cancer: state-of-the-art and new perspectives
title_full Neoadjuvant treatment of biliary tract cancer: state-of-the-art and new perspectives
title_fullStr Neoadjuvant treatment of biliary tract cancer: state-of-the-art and new perspectives
title_full_unstemmed Neoadjuvant treatment of biliary tract cancer: state-of-the-art and new perspectives
title_short Neoadjuvant treatment of biliary tract cancer: state-of-the-art and new perspectives
title_sort neoadjuvant treatment of biliary tract cancer: state-of-the-art and new perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095316/
https://www.ncbi.nlm.nih.gov/pubmed/30191029
http://dx.doi.org/10.2217/hep.15.43
work_keys_str_mv AT imperatorimarco neoadjuvanttreatmentofbiliarytractcancerstateoftheartandnewperspectives
AT donofrioloretta neoadjuvanttreatmentofbiliarytractcancerstateoftheartandnewperspectives
AT marruccieleonora neoadjuvanttreatmentofbiliarytractcancerstateoftheartandnewperspectives
AT pantanofrancesco neoadjuvanttreatmentofbiliarytractcancerstateoftheartandnewperspectives
AT zoccolialice neoadjuvanttreatmentofbiliarytractcancerstateoftheartandnewperspectives
AT toninigiuseppe neoadjuvanttreatmentofbiliarytractcancerstateoftheartandnewperspectives